Malignant transformation of oral leukoplakia: Systematic review and meta‐analysis of the last 5 years
Objective Oral leukoplakia (OL) is the most frequently encountered oral potentially malignant disorder. The aims of this systematic review are to estimate the overall malignant transformation of OL and to assess the risk factors associated with malignant transformation of OL published in the last 5 ...
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| Published in | Oral diseases Vol. 27; no. 8; pp. 1881 - 1895 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
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01.11.2021
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| Abstract | Objective
Oral leukoplakia (OL) is the most frequently encountered oral potentially malignant disorder. The aims of this systematic review are to estimate the overall malignant transformation of OL and to assess the risk factors associated with malignant transformation of OL published in the last 5 years (2015–2020).
Materials and Methods
We performed a bibliographic search in PubMed, Scopus, Web of Science, Embase, and Cochrane databases with keywords “oral leukoplakia”, “oral cancer”, “oral carcinoma” and “oral squamous cell carcinoma”. Meta‐analysis was conducted using a random‐effects model.
Results
Twenty‐four studies were selected, that reported a total of 16,604 patients. Malignant transformation proportion varied between 1.1% and 40.8%. Female gender, non‐homogeneous clinical type, and presence of epithelial dysplasia were significantly related to MT. Other risk factors previously suggested did not show significant results.
Conclusions
The pooled proportion of malignant transformation MT was 9.8% (95% CI: 7.9–11.7). It is necessary to continue to conduct well‐designed prospective clinicopathological studies on OL, using a uniform definition for OL to reduce the risk of bias for evaluating various factors associated with the MT. |
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| AbstractList | Objective
Oral leukoplakia (OL) is the most frequently encountered oral potentially malignant disorder. The aims of this systematic review are to estimate the overall malignant transformation of OL and to assess the risk factors associated with malignant transformation of OL published in the last 5 years (2015–2020).
Materials and Methods
We performed a bibliographic search in PubMed, Scopus, Web of Science, Embase, and Cochrane databases with keywords “oral leukoplakia”, “oral cancer”, “oral carcinoma” and “oral squamous cell carcinoma”. Meta‐analysis was conducted using a random‐effects model.
Results
Twenty‐four studies were selected, that reported a total of 16,604 patients. Malignant transformation proportion varied between 1.1% and 40.8%. Female gender, non‐homogeneous clinical type, and presence of epithelial dysplasia were significantly related to MT. Other risk factors previously suggested did not show significant results.
Conclusions
The pooled proportion of malignant transformation MT was 9.8% (95% CI: 7.9–11.7). It is necessary to continue to conduct well‐designed prospective clinicopathological studies on OL, using a uniform definition for OL to reduce the risk of bias for evaluating various factors associated with the MT. Oral leukoplakia (OL) is the most frequently encountered oral potentially malignant disorder. The aims of this systematic review are to estimate the overall malignant transformation of OL and to assess the risk factors associated with malignant transformation of OL published in the last 5 years (2015-2020). We performed a bibliographic search in PubMed, Scopus, Web of Science, Embase, and Cochrane databases with keywords "oral leukoplakia", "oral cancer", "oral carcinoma" and "oral squamous cell carcinoma". Meta-analysis was conducted using a random-effects model. Twenty-four studies were selected, that reported a total of 16,604 patients. Malignant transformation proportion varied between 1.1% and 40.8%. Female gender, non-homogeneous clinical type, and presence of epithelial dysplasia were significantly related to MT. Other risk factors previously suggested did not show significant results. The pooled proportion of malignant transformation MT was 9.8% (95% CI: 7.9-11.7). It is necessary to continue to conduct well-designed prospective clinicopathological studies on OL, using a uniform definition for OL to reduce the risk of bias for evaluating various factors associated with the MT. Oral leukoplakia (OL) is the most frequently encountered oral potentially malignant disorder. The aims of this systematic review are to estimate the overall malignant transformation of OL and to assess the risk factors associated with malignant transformation of OL published in the last 5 years (2015-2020).OBJECTIVEOral leukoplakia (OL) is the most frequently encountered oral potentially malignant disorder. The aims of this systematic review are to estimate the overall malignant transformation of OL and to assess the risk factors associated with malignant transformation of OL published in the last 5 years (2015-2020).We performed a bibliographic search in PubMed, Scopus, Web of Science, Embase, and Cochrane databases with keywords "oral leukoplakia", "oral cancer", "oral carcinoma" and "oral squamous cell carcinoma". Meta-analysis was conducted using a random-effects model.MATERIALS AND METHODSWe performed a bibliographic search in PubMed, Scopus, Web of Science, Embase, and Cochrane databases with keywords "oral leukoplakia", "oral cancer", "oral carcinoma" and "oral squamous cell carcinoma". Meta-analysis was conducted using a random-effects model.Twenty-four studies were selected, that reported a total of 16,604 patients. Malignant transformation proportion varied between 1.1% and 40.8%. Female gender, non-homogeneous clinical type, and presence of epithelial dysplasia were significantly related to MT. Other risk factors previously suggested did not show significant results.RESULTSTwenty-four studies were selected, that reported a total of 16,604 patients. Malignant transformation proportion varied between 1.1% and 40.8%. Female gender, non-homogeneous clinical type, and presence of epithelial dysplasia were significantly related to MT. Other risk factors previously suggested did not show significant results.The pooled proportion of malignant transformation MT was 9.8% (95% CI: 7.9-11.7). It is necessary to continue to conduct well-designed prospective clinicopathological studies on OL, using a uniform definition for OL to reduce the risk of bias for evaluating various factors associated with the MT.CONCLUSIONSThe pooled proportion of malignant transformation MT was 9.8% (95% CI: 7.9-11.7). It is necessary to continue to conduct well-designed prospective clinicopathological studies on OL, using a uniform definition for OL to reduce the risk of bias for evaluating various factors associated with the MT. ObjectiveOral leukoplakia (OL) is the most frequently encountered oral potentially malignant disorder. The aims of this systematic review are to estimate the overall malignant transformation of OL and to assess the risk factors associated with malignant transformation of OL published in the last 5 years (2015–2020).Materials and MethodsWe performed a bibliographic search in PubMed, Scopus, Web of Science, Embase, and Cochrane databases with keywords “oral leukoplakia”, “oral cancer”, “oral carcinoma” and “oral squamous cell carcinoma”. Meta‐analysis was conducted using a random‐effects model.ResultsTwenty‐four studies were selected, that reported a total of 16,604 patients. Malignant transformation proportion varied between 1.1% and 40.8%. Female gender, non‐homogeneous clinical type, and presence of epithelial dysplasia were significantly related to MT. Other risk factors previously suggested did not show significant results.ConclusionsThe pooled proportion of malignant transformation MT was 9.8% (95% CI: 7.9–11.7). It is necessary to continue to conduct well‐designed prospective clinicopathological studies on OL, using a uniform definition for OL to reduce the risk of bias for evaluating various factors associated with the MT. |
| Author | Lafuente‐Ibáñez de Mendoza, Irene Warnakulasuriya, Saman Aguirre‐Urizar, José M. |
| Author_xml | – sequence: 1 givenname: José M. orcidid: 0000-0002-2652-0755 surname: Aguirre‐Urizar fullname: Aguirre‐Urizar, José M. email: josemanuel.aguirre@ehu.eus organization: University of the Basque Country/EHU – sequence: 2 givenname: Irene orcidid: 0000-0001-7704-4122 surname: Lafuente‐Ibáñez de Mendoza fullname: Lafuente‐Ibáñez de Mendoza, Irene organization: University of the Basque Country/EHU – sequence: 3 givenname: Saman orcidid: 0000-0003-2103-0746 surname: Warnakulasuriya fullname: Warnakulasuriya, Saman organization: King’s College London and WHO Collaborating Centre for Oral Cancer |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33606345$$D View this record in MEDLINE/PubMed |
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Oral leukoplakia (OL) is the most frequently encountered oral potentially malignant disorder. The aims of this systematic review are to estimate the... Oral leukoplakia (OL) is the most frequently encountered oral potentially malignant disorder. The aims of this systematic review are to estimate the overall... ObjectiveOral leukoplakia (OL) is the most frequently encountered oral potentially malignant disorder. The aims of this systematic review are to estimate the... |
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| SubjectTerms | Carcinoma, Squamous Cell Cell Transformation, Neoplastic Dysplasia Female Humans Leukokeratosis Leukoplakia, Oral malignant transformation Meta-analysis Mouth Neoplasms Oral cancer Oral carcinoma oral leukoplakia Oral squamous cell carcinoma Prospective Studies risk Risk factors Squamous cell carcinoma Systematic review |
| Title | Malignant transformation of oral leukoplakia: Systematic review and meta‐analysis of the last 5 years |
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