Alternative splicing regulation of membrane trafficking genes during myogenesis

• Published in: RNA (Cambridge) Vol. 28; no. 4; pp. 523 - 540
• Main Authors: Hinkle, Emma R, Wiedner, Hannah J, Torres, Eduardo V, Jackson, Micaela, Black, Adam J, Blue, R Eric, Harris, Sarah E, Guzman, Bryan B, Gentile, Gabrielle M, Lee, Eunice Y, Tsai, Yi-Hsuan, Parker, Joel, Dominguez, Daniel, Giudice, Jimena
• Format: Journal Article
• Language: English
• Published: United States Cold Spring Harbor Laboratory Press 01.04.2022
• Subjects: Alternative Splicing; Animals; Cell differentiation; Chromatin; Exons; Fetuses; Gene regulation; Heterogeneous-Nuclear Ribonucleoproteins - genetics; Heterogeneous-Nuclear Ribonucleoproteins - metabolism; Membrane trafficking; Mice; Muscle Development - genetics; Muscles; Myogenesis; Polypyrimidine Tract-Binding Protein - genetics; Polypyrimidine Tract-Binding Protein - metabolism; Proteins; RNA-binding protein; RNA-binding proteins; alternative splicing; myogenesis; membrane trafficking

Alternative splicing transitions occur during organ development, and, in numerous diseases, splicing programs revert to fetal isoform expression. We previously found that extensive splicing changes occur during postnatal mouse heart development in genes encoding proteins involved in vesicle-mediated...