Axonal regeneration of sensory nerves is delayed by continuous intrathecal infusion of nerve growth factor

• Published in: Neuroscience Vol. 76; no. 4; pp. 1153 - 1158
• Main Author: Gold, B.G
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 01.02.1997; Elsevier
• Subjects: Animals; axonal regeneration; Axons - drug effects; Biological and medical sciences; Development. Senescence. Regeneration. Transplantation; dorsal root ganglion; Fundamental and applied biological sciences. Psychology; Ganglia, Spinal - cytology; Ganglia, Spinal - drug effects; Injections, Spinal; Male; Nerve Crush; nerve growth factor; Nerve Growth Factors - administration & dosage; Nerve Growth Factors - pharmacology; Nerve Regeneration - drug effects; Neurons, Afferent - drug effects; rat; Rats; Rats, Sprague-Dawley; sciatic nerve; Sciatic Nerve - drug effects; Sciatic Nerve - physiology; Sciatic Nerve - ultrastructure; sensory neurons; Vertebrates: nervous system and sense organs; axonal regeneration; rat; nerve growth factor; DRG, dorsal root ganglion; dorsal root ganglion; NGF, nerve growth factor; sensory neurons; sciatic nerve; Regeneration; Spinal cord; Vertebrata; Mammalia; Rat; Rodentia; Central nervous system; Nerve growth factor; Sensory neuron; Spinal ganglion; Sciatic nerve

While it is well established that nerve growth factor is growth promoting for sensory neurons in culture, it is unclear whether it serves such a function in vivo. In fact, our previous studies led to the hypothesis that nerve growth factor could actually impair axonal regeneration by reducing the ne...