Rapid prototyping of three-dimensional microfluidic mixers in glass by femtosecond laser direct writing
The creation of complex three-dimensional (3D) microfluidic systems has attracted significant attention from both scientific and applied research communities. However, it is still a formidable challenge to build 3D microfluidic structures with arbitrary configurations using conventional planar litho...
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| Published in | Lab on a chip Vol. 12; no. 4; pp. 746 - 749 |
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| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
01.01.2012
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| Subjects | |
| Online Access | Get full text |
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| Abstract | The creation of complex three-dimensional (3D) microfluidic systems has attracted significant attention from both scientific and applied research communities. However, it is still a formidable challenge to build 3D microfluidic structures with arbitrary configurations using conventional planar lithographic fabrication methods. Here, we demonstrate rapid fabrication of high-aspect-ratio microfluidic channels with various 3D configurations in glass substrates by femtosecond laser direct writing. Based on this approach, we demonstrate a 3D passive microfluidic mixer and characterize its functionalities. This technology will enable rapid construction of complex 3D microfluidic devices for a wide array of lab-on-a-chip applications. |
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| AbstractList | The creation of complex three-dimensional (3D) microfluidic systems has attracted significant attention from both scientific and applied research communities. However, it is still a formidable challenge to build 3D microfluidic structures with arbitrary configurations using conventional planar lithographic fabrication methods. Here, we demonstrate rapid fabrication of high-aspect-ratio microfluidic channels with various 3D configurations in glass substrates by femtosecond laser direct writing. Based on this approach, we demonstrate a 3D passive microfluidic mixer and characterize its functionalities. This technology will enable rapid construction of complex 3D microfluidic devices for a wide array of lab-on-a-chip applications. The creation of complex three-dimensional (3D) microfluidic systems has attracted significant attention from both scientific and applied research communities. However, it is still a formidable challenge to build 3D microfluidic structures with arbitrary configurations using conventional planar lithographic fabrication methods. Here, we demonstrate rapid fabrication of high-aspect-ratio microfluidic channels with various 3D configurations in glass substrates by femtosecond laser direct writing. Based on this approach, we demonstrate a 3D passive microfluidic mixer and characterize its functionalities. This technology will enable rapid construction of complex 3D microfluidic devices for a wide array of lab-on-a-chip applications.The creation of complex three-dimensional (3D) microfluidic systems has attracted significant attention from both scientific and applied research communities. However, it is still a formidable challenge to build 3D microfluidic structures with arbitrary configurations using conventional planar lithographic fabrication methods. Here, we demonstrate rapid fabrication of high-aspect-ratio microfluidic channels with various 3D configurations in glass substrates by femtosecond laser direct writing. Based on this approach, we demonstrate a 3D passive microfluidic mixer and characterize its functionalities. This technology will enable rapid construction of complex 3D microfluidic devices for a wide array of lab-on-a-chip applications. |
| Author | Shen, Yinglong Song, Jiangxin Xu, Zhizhan Liao, Yang Li, En Midorikawa, Katsumi Cheng, Ya Luo, Yong Chen, Danping Sugioka, Koji |
| Author_xml | – sequence: 1 givenname: Yang surname: Liao fullname: Liao, Yang – sequence: 2 givenname: Jiangxin surname: Song fullname: Song, Jiangxin – sequence: 3 givenname: En surname: Li fullname: Li, En – sequence: 4 givenname: Yong surname: Luo fullname: Luo, Yong – sequence: 5 givenname: Yinglong surname: Shen fullname: Shen, Yinglong – sequence: 6 givenname: Danping surname: Chen fullname: Chen, Danping – sequence: 7 givenname: Ya surname: Cheng fullname: Cheng, Ya – sequence: 8 givenname: Zhizhan surname: Xu fullname: Xu, Zhizhan – sequence: 9 givenname: Koji surname: Sugioka fullname: Sugioka, Koji – sequence: 10 givenname: Katsumi surname: Midorikawa fullname: Midorikawa, Katsumi |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/22231027$$D View this record in MEDLINE/PubMed |
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| SubjectTerms | Arrays Construction Femtosecond Glass Lasers Microfluidic Analytical Techniques - instrumentation Microfluidics Mixers Three dimensional |
| Title | Rapid prototyping of three-dimensional microfluidic mixers in glass by femtosecond laser direct writing |
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