Use of in vitro 3D tissue models in genotoxicity testing: Strategic fit, validation status and way forward. Report of the working group from the 7th International Workshop on Genotoxicity Testing (IWGT)

• Published in: Mutation Research/Genetic Toxicology and Environmental Mutagenesis Vol. 850-851; p. 503135
• Main Authors: Pfuhler, Stefan, van Benthem, Jan, Curren, Rodger, Doak, Shareen H., Dusinska, Maria, Hayashi, Makoto, Heflich, Robert H., Kidd, Darren, Kirkland, David, Luan, Yang, Ouedraogo, Gladys, Reisinger, Kerstin, Sofuni, Toshio, van Acker, Frédérique, Yang, Ying, Corvi, Raffaella
• Format: Journal Article
• Language: English; Japanese
• Published: Elsevier B.V 01.02.2020; Elsevier BV
• Subjects: 3D airway models; Comet assay; DNA damage; In vitro genotoxicity testing; Liver spheroids; Micronucleus test; Reconstructed human skin; Micronucleus test; In vitro genotoxicity testing; DNA damage; Reconstructed human skin; 3D airway models; Comet assay; Liver spheroids

•Extensive progress made in development of 3D organ-based genotoxicity assays.•3D culture models represent major exposure routes: dermal, oral, inhalation.•The 3D skin comet and MN assays are considered mature and sufficiently validated.•Liver and airway model-based genotoxicity assays show promise...