Sorption of nicotine to cellulose powders

The purpose of this study was to investigate the influence of the crystallinity, surface area, and pore volume of cellulose powders on the loading, release, and stability of nicotine. Four different types of cellulose powders with varying crystallinity index, surface area, and pore volume were produ...

Full description

Saved in:

Bibliographic Details
Published in	European journal of pharmaceutical sciences Vol. 22; no. 4; pp. 279 - 286
Main Authors	Mihranyan, Albert, Andersson, Sven-Börje, Ek, Ragnar
Format	Journal Article
Language	English
Published	Shannon Elsevier B.V 01.07.2004 Elsevier
Subjects	Adsorption Air Biological and medical sciences Cellulose Cellulose - chemistry Chemistry, Pharmaceutical - methods Cladophora sp. algae Crystallinity Crystallography General pharmacology Medical sciences Microcrystalline cellulose Microscopy, Electron, Scanning Nicotine Nicotine - chemistry Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Pore volume Powders Surface Properties Pore volume Crystallinity Microcrystalline cellulose Cellulose Nicotine Cladophora sp. algae Microcrystalline material Pharmaceutical technology Algae Powder Sorption Alkaloid Pore Thallophyta
Online Access	Get full text

Cover

Loading…

Abstract	The purpose of this study was to investigate the influence of the crystallinity, surface area, and pore volume of cellulose powders on the loading, release, and stability of nicotine. Four different types of cellulose powders with varying crystallinity index, surface area, and pore volume were produced and characterized. The powders were loaded with nicotine by rotary evaporation from an ethanol solution and by adsorption from nicotine-saturated air. The release of nicotine from loaded cellulose powders into both a passing airstream and water was investigated by UV spectroscopy. A 3-month stability study was conducted and the total sum of nicotine oxidation products was measured. Nicotine loading and release were independent of cellulose powder crystallinity, whereas it was possible to load more nicotine on the cellulose powder with a large surface area and pore volume. Release into water was very rapid and almost complete for all samples. Nicotine was most stable when loaded on the powder with a large surface area and pore volume. Highly porous cellulose matrices could be useful for stabilization and handling of both nicotine and other liquid active pharmaceutical ingredients.
AbstractList	The purpose of this study was to investigate the influence of the crystallinity, surface area, and pore volume of cellulose powders on the loading, release, and stability of nicotine. Four different types of cellulose powders with varying crystallinity index, surface area, and pore volume were produced and characterized. The powders were loaded with nicotine by rotary evaporation from an ethanol solution and by adsorption from nicotine-saturated air. The release of nicotine from loaded cellulose powders into both a passing airstream and water was investigated by UV spectroscopy. A 3-month stability study was conducted and the total sum of nicotine oxidation products was measured. Nicotine loading and release were independent of cellulose powder crystallinity, whereas it was possible to load more nicotine on the cellulose powder with a large surface area and pore volume. Release into water was very rapid and almost complete for all samples. Nicotine was most stable when loaded on the powder with a large surface area and pore volume. Highly porous cellulose matrices could be useful for stabilization and handling of both nicotine and other liquid active pharmaceutical ingredients.
Author	Mihranyan, Albert Andersson, Sven-Börje Ek, Ragnar
Author_xml	– sequence: 1 givenname: Albert surname: Mihranyan fullname: Mihranyan, Albert organization: Department of Pharmacy, Uppsala University, P.O. Box 580, Uppsala, SE-751 23, Sweden – sequence: 2 givenname: Sven-Börje surname: Andersson fullname: Andersson, Sven-Börje organization: Pharmacia Consumer Healthcare, P.O. Box 941, Helsingborg, SE-251 09, Sweden – sequence: 3 givenname: Ragnar surname: Ek fullname: Ek, Ragnar email: ragnar.ek@farmaci.uu.se organization: Department of Pharmacy, Uppsala University, P.O. Box 580, Uppsala, SE-751 23, Sweden
BackLink	http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15893426$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/15196584$$D View this record in MEDLINE/PubMed https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-67538$$DView record from Swedish Publication Index
BookMark	eNp9kEtLxDAUhYMozkP_gAvpRkGk9aZN2xTcDL5BcKG4DWl6Ixk6TU1axX9vhhnUlasLl-8cDt-M7Ha2Q0KOKCQUaHGxTHDZ-yQFYAlkCdB0h0wpL6sYyhR2yRSqlMdQ8XJCZt4vAaDgJeyTCc1pVeScTcnZs3X9YGwXWR11RtnBdBgNNlLYtmNrPUa9_WzQ-QOyp2Xr8XB75-Tl9ubl6j5-fLp7uFo8xopRPsQaasmgUprWqHReq5JjWWOeomSs4CC11MA4r-u8YVV4o8pQV3mhtEIpszk539T6T-zHWvTOrKT7ElYacW1eF8K6NzGOoijzjAf6dEP3zr6P6AexMn49XXZoRy-ChzRnJQ1gugGVs9471D_FFMTapliKtU2xtikgE8FmCB1v28d6hc1vZKsvACdbQHolW-1kp4z_w_EqY2kRuMsNh0Hch0EnvDLYKWyMQzWIxpr_dnwDG62VzA
CitedBy_id	crossref_primary_10_1007_s10570_015_0772_2 crossref_primary_10_1002_cjoc_201200580 crossref_primary_10_1016_j_ijpharm_2013_11_032 crossref_primary_10_1016_j_biortech_2010_12_103 crossref_primary_10_1016_j_carbpol_2010_01_019 crossref_primary_10_1016_j_carbpol_2016_08_053 crossref_primary_10_1021_acs_biomac_6b00053 crossref_primary_10_1021_jp805123w crossref_primary_10_1208_s12249_012_9790_7 crossref_primary_10_2174_1567201816666191106102740 crossref_primary_10_1016_j_carbpol_2017_05_002 crossref_primary_10_1016_j_apsusc_2011_04_076 crossref_primary_10_1016_j_colsurfb_2008_02_016 crossref_primary_10_1016_j_talanta_2012_03_038 crossref_primary_10_1016_j_clay_2009_03_004 crossref_primary_10_1208_s12249_011_9633_y crossref_primary_10_1016_j_biortech_2024_130850 crossref_primary_10_1016_j_ijbiomac_2024_129422 crossref_primary_10_1016_j_ejps_2005_10_002 crossref_primary_10_4028_www_scientific_net_AMR_610_613_3591 crossref_primary_10_3390_molecules23030601 crossref_primary_10_1016_j_aca_2008_10_019 crossref_primary_10_3390_coatings14020243 crossref_primary_10_1007_s10570_015_0840_7 crossref_primary_10_1021_acssuschemeng_7b01169 crossref_primary_10_1002_pen_24330 crossref_primary_10_1016_j_colsurfb_2009_06_033 crossref_primary_10_4028_www_scientific_net_AMR_664_259 crossref_primary_10_1002_adhm_201300641 crossref_primary_10_1039_C3RA45553J crossref_primary_10_1021_jf801314n crossref_primary_10_1002_app_32959 crossref_primary_10_1021_ie901351h crossref_primary_10_1016_j_ijpharm_2023_123243 crossref_primary_10_1021_es050914r crossref_primary_10_3390_pharmaceutics11020068 crossref_primary_10_1016_j_jaap_2016_02_021 crossref_primary_10_1016_j_tca_2014_05_023 crossref_primary_10_1021_bm5002944 crossref_primary_10_4028_www_scientific_net_AMM_295_298_123
Cites_doi	10.1351/pac198557040603 10.2165/00003088-198712010-00003 10.1021/cr60092a004 10.1016/0378-5173(95)00034-G 10.1016/0378-8741(90)90068-5 10.1001/jama.260.11.1575 10.1007/s002280050324 10.1016/S0939-6411(98)00102-7 10.1007/BF00846161 10.1016/j.ijpharm.2003.09.030 10.1093/ajhp/52.3.265 10.1177/004051756503500605 10.1177/004051755902901003 10.1016/S0169-5002(97)00648-X 10.1016/B978-044450095-3/50006-1 10.1002/(SICI)1099-1352(199812)11:1/6<263::AID-JMR437>3.0.CO;2-G 10.1093/jaoac/81.3.540 10.1159/000062069
ContentType	Journal Article
Copyright	2004 Elsevier B.V. 2005 INIST-CNRS
Copyright_xml	– notice: 2004 Elsevier B.V. – notice: 2005 INIST-CNRS
DBID	IQODW CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 ADTPV AOWAS DF2
DOI	10.1016/j.ejps.2004.03.012
DatabaseName	Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef MEDLINE - Academic SwePub SwePub Articles SWEPUB Uppsala universitet
DatabaseTitle	MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef MEDLINE - Academic
DatabaseTitleList	MEDLINE - Academic MEDLINE
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Pharmacy, Therapeutics, & Pharmacology
EISSN	1879-0720
EndPage	286
ExternalDocumentID	oai_DiVA_org_uu_67538 10_1016_j_ejps_2004_03_012 15196584 15893426 S0928098704000776
Genre	Journal Article
GroupedDBID	--- --K --M .~1 0R~ 0SF 1B1 1RT 1~. 1~5 29G 4.4 457 4G. 53G 5GY 5VS 7-5 71M 8P~ 9JM AABNK AACTN AAEDT AAEDW AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AATCM AAXUO ABFNM ABFRF ABJNI ABLJU ABMAC ABXDB ABYKQ ABZDS ACDAQ ACGFO ACGFS ACIUM ACRLP ADBBV ADEZE ADMUD AEBSH AEFWE AEKER AENEX AFKWA AFTJW AFXIZ AGHFR AGUBO AGYEJ AHHHB AIEXJ AIKHN AITUG AJBFU AJOXV ALCLG ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC C45 CS3 DU5 EBS EFJIC EFLBG EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA GROUPED_DOAJ HMT HVGLF HZ~ IHE J1W KOM M34 M41 MO0 N9A O-L O9- OAUVE OGGZJ OK1 OVD OZT P-8 P-9 P2P PC. Q38 R2- RIG ROL RPZ SCC SDF SDG SDP SES SEW SPCBC SPT SSP SSZ T5K TEORI WUQ ~G- ABPIF ABPTK IQODW AAXKI ADVLN AFJKZ AKRWK CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 ADTPV AOWAS DF2
ID	FETCH-LOGICAL-c418t-f0ba409cf1becf5bc78e7be52ea44680afaf0488bb5d4952eec3ef956cfceaa3
IEDL.DBID	AIKHN
ISSN	0928-0987
IngestDate	Tue Oct 01 22:38:32 EDT 2024 Fri Oct 25 05:26:50 EDT 2024 Thu Sep 26 17:25:08 EDT 2024 Sat Sep 28 07:42:52 EDT 2024 Sun Oct 22 16:08:38 EDT 2023 Fri Feb 23 02:34:48 EST 2024
IsPeerReviewed	true
IsScholarly	true
Issue	4
Keywords	Pore volume Crystallinity Microcrystalline cellulose Cellulose Nicotine Cladophora sp. algae Microcrystalline material Pharmaceutical technology Algae Powder Sorption Alkaloid Pore Thallophyta
Language	English
License	CC BY 4.0
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c418t-f0ba409cf1becf5bc78e7be52ea44680afaf0488bb5d4952eec3ef956cfceaa3
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
PMID	15196584
PQID	72025471
PQPubID	23479
PageCount	8
ParticipantIDs	swepub_primary_oai_DiVA_org_uu_67538 proquest_miscellaneous_72025471 crossref_primary_10_1016_j_ejps_2004_03_012 pubmed_primary_15196584 pascalfrancis_primary_15893426 elsevier_sciencedirect_doi_10_1016_j_ejps_2004_03_012
PublicationCentury	2000
PublicationDate	2004-07-01
PublicationDateYYYYMMDD	2004-07-01
PublicationDate_xml	– month: 07 year: 2004 text: 2004-07-01 day: 01
PublicationDecade	2000
PublicationPlace	Shannon
PublicationPlace_xml	– name: Shannon – name: Netherlands
PublicationTitle	European journal of pharmaceutical sciences
PublicationTitleAlternate	Eur J Pharm Sci
PublicationYear	2004
Publisher	Elsevier B.V Elsevier
Publisher_xml	– name: Elsevier B.V – name: Elsevier
References	Segal, L., Cleery, J. J., Martin Jr., A. E., Conrad, C. M., 1959. An empirical method for estimating the degree of crystallinity of native cellulose using the X-ray diffractometer, Textile Res. J., 786–794. Russel (BIB19) 1988; 261 Jackson (BIB12) 1941; 29 European Pharmacopoeia, fourth ed., Strasbourg, 2002. Suzuki, Nakagami (BIB21) 1999; 47 Ek, Gustafsson, Nutt, Iversen, Nyström (BIB4) 1998; 11 Merck Index, 13th ed., Merck & Co., Inc., USA, 2001, p. 6552. Svensson (BIB22) 1987; 12 Fagerström (BIB7) 1982; 5 Harvey (BIB10) 1990; 28 Yiannos (BIB25) 1965; 48 Banyasz, J.L., 1999. The physical chemistry of nicotine. In: Gorrod, J.W., Peyton III, J. (Eds.), Analytical Determination of Nicotine and Related Compounds and Their Metabolites, Elsevier, Amsterdam, p. 154. US Surgeon General, 1988. The health consequences of smoking—Nicotine addiction, US Department of Health and Human Services, USPGO, Washington, DC. Boyle (BIB2) 1997; 17 Haxby (BIB11) 1995; 52 Lunell, Molander, Andersson (BIB13) 1997; 52 Ek, Lennholm, Davidsson, Nyström, Ragnarsson (BIB3) 1995; 122 Fortmann, Killen, Telch (BIB8) 1988; 260 Nasr, Reepmeyer, Tang (BIB16) 1998; 81 Sing, Everett, Haul, Moscou, Pierotti, Rouquerol, Siemienewska (BIB20) 1985; 57 . Handbook of Pharmaceutical Excipients, 1994. Wade, A., Weller, P.J. (Eds.), second ed., The Pharmaceutical Press, London, p. 84. Patil, N.B., Dweltz, N.E., Radhakrishnan, T., 1965. Studies on decrystallization of cotton, Textile Res. J., 517–523. Mihranyan, Piñas Llagostera, Karmhag, Strømme, Ek (BIB15) 2004; 269 Encyclopaedia Britannica, “Dynamite”, Encyclopaedia Britannica Online, 28 November 2003 Wyser C., Bolliger C. T., 1997. Smoking related disorders. In: Bolliger C.T., Fagerström, K.O. (Eds.), The Tobacco Epidemic. Progress in Respiratory Research Series, vol. 28, S. Krager, Basel, pp. 78–106. 10.1016/j.ejps.2004.03.012_BIB17 10.1016/j.ejps.2004.03.012_BIB18 Yiannos (10.1016/j.ejps.2004.03.012_BIB25) 1965; 48 10.1016/j.ejps.2004.03.012_BIB14 Nasr (10.1016/j.ejps.2004.03.012_BIB16) 1998; 81 Ek (10.1016/j.ejps.2004.03.012_BIB4) 1998; 11 Jackson (10.1016/j.ejps.2004.03.012_BIB12) 1941; 29 Harvey (10.1016/j.ejps.2004.03.012_BIB10) 1990; 28 Haxby (10.1016/j.ejps.2004.03.012_BIB11) 1995; 52 Fortmann (10.1016/j.ejps.2004.03.012_BIB8) 1988; 260 Svensson (10.1016/j.ejps.2004.03.012_BIB22) 1987; 12 Boyle (10.1016/j.ejps.2004.03.012_BIB2) 1997; 17 Mihranyan (10.1016/j.ejps.2004.03.012_BIB15) 2004; 269 Ek (10.1016/j.ejps.2004.03.012_BIB3) 1995; 122 10.1016/j.ejps.2004.03.012_BIB24 Sing (10.1016/j.ejps.2004.03.012_BIB20) 1985; 57 10.1016/j.ejps.2004.03.012_BIB23 10.1016/j.ejps.2004.03.012_BIB9 Lunell (10.1016/j.ejps.2004.03.012_BIB13) 1997; 52 10.1016/j.ejps.2004.03.012_BIB5 10.1016/j.ejps.2004.03.012_BIB6 Russel (10.1016/j.ejps.2004.03.012_BIB19) 1988; 261 Fagerström (10.1016/j.ejps.2004.03.012_BIB7) 1982; 5 10.1016/j.ejps.2004.03.012_BIB1 Suzuki (10.1016/j.ejps.2004.03.012_BIB21) 1999; 47
References_xml	– volume: 52 start-page: 265 year: 1995 end-page: 281 ident: BIB11 article-title: Treatment of nicotine dependence publication-title: Am. J. Health-Syst. Pharm. contributor: fullname: Haxby – volume: 261 start-page: 63 year: 1988 end-page: 94 ident: BIB19 article-title: Nicotine replacement: the role of blood nicotine levels, their rate of change, and nicotine tolerance publication-title: Prog. Clin. Biol. Res. contributor: fullname: Russel – volume: 52 start-page: 495 year: 1997 end-page: 500 ident: BIB13 article-title: Temperature dependency of the release and bioavailability of nicotine from a nicotine vapour inhaler; in vitro/in vivo correlation publication-title: Eur. J. Pharmacol. contributor: fullname: Andersson – volume: 28 start-page: 117 year: 1990 end-page: 128 ident: BIB10 article-title: Stability of cannabioids in dried samples of cannabis dating from around 1896–1905 publication-title: J. Ethnopharm. contributor: fullname: Harvey – volume: 269 start-page: 433 year: 2004 end-page: 442 ident: BIB15 article-title: Moisture sorption by cellulose powders of varying crystallinity publication-title: Int. J. Pharm. contributor: fullname: Ek – volume: 12 start-page: 30 year: 1987 end-page: 40 ident: BIB22 article-title: Clinical pharmacokinetics of nicotine publication-title: Clin. Pharmacokin. contributor: fullname: Svensson – volume: 57 start-page: 603 year: 1985 end-page: 619 ident: BIB20 article-title: Reporting physisorption data for gas/solid systems with special reference to the determination of surface area and porosity (recommendations) publication-title: Pure Appl. Chem. contributor: fullname: Siemienewska – volume: 5 start-page: 343 year: 1982 end-page: 351 ident: BIB7 article-title: A comparison of physiological and pharmacological treatment in smoking cessation publication-title: J. Behav. Med. contributor: fullname: Fagerström – volume: 29 start-page: 123 year: 1941 end-page: 197 ident: BIB12 article-title: Alkaloids of tobacco publication-title: Chem. Rev. contributor: fullname: Jackson – volume: 122 start-page: 49 year: 1995 end-page: 56 ident: BIB3 article-title: Pore swelling in beads made of cellulose fibres and fibre fragments publication-title: Int. J. Pharm. contributor: fullname: Ragnarsson – volume: 48 start-page: 494 year: 1965 end-page: 496 ident: BIB25 article-title: Swellability of pulps determined by isopropanol retention publication-title: Tappi contributor: fullname: Yiannos – volume: 47 start-page: 225 year: 1999 end-page: 230 ident: BIB21 article-title: Effect of crystallinity of microcrystalline cellulose on the compactability and dissolution of tablets publication-title: Eur. J. Pharm. Biopharm. contributor: fullname: Nakagami – volume: 260 start-page: 1575 year: 1988 end-page: 1580 ident: BIB8 article-title: Minimal contact treatment for smoking cessation. A placebo controlled trial of nicotine polacrilex and self-directed relapse prevention: initial results of the Stanford Stop Smoking Project publication-title: JAMA contributor: fullname: Telch – volume: 17 start-page: 1 year: 1997 end-page: 60 ident: BIB2 article-title: Cancer, cigarette smoking and premature death in Europe: a review including the recommendations of European Cancer Experts Consensus Meeting, Helsinki, October 1996 publication-title: Lung Cancer contributor: fullname: Boyle – volume: 11 start-page: 263 year: 1998 end-page: 265 ident: BIB4 article-title: Cellulose powders from publication-title: J. Mol. Recogn. contributor: fullname: Nyström – volume: 81 start-page: 540 year: 1998 end-page: 543 ident: BIB16 article-title: In vitro study of nicotine release from smokeless tobacco publication-title: J. AOAC Int. contributor: fullname: Tang – volume: 57 start-page: 603 issue: 4 year: 1985 ident: 10.1016/j.ejps.2004.03.012_BIB20 article-title: Reporting physisorption data for gas/solid systems with special reference to the determination of surface area and porosity (recommendations) publication-title: Pure Appl. Chem. doi: 10.1351/pac198557040603 contributor: fullname: Sing – volume: 12 start-page: 30 year: 1987 ident: 10.1016/j.ejps.2004.03.012_BIB22 article-title: Clinical pharmacokinetics of nicotine publication-title: Clin. Pharmacokin. doi: 10.2165/00003088-198712010-00003 contributor: fullname: Svensson – volume: 29 start-page: 123 year: 1941 ident: 10.1016/j.ejps.2004.03.012_BIB12 article-title: Alkaloids of tobacco publication-title: Chem. Rev. doi: 10.1021/cr60092a004 contributor: fullname: Jackson – ident: 10.1016/j.ejps.2004.03.012_BIB14 – volume: 122 start-page: 49 year: 1995 ident: 10.1016/j.ejps.2004.03.012_BIB3 article-title: Pore swelling in beads made of cellulose fibres and fibre fragments publication-title: Int. J. Pharm. doi: 10.1016/0378-5173(95)00034-G contributor: fullname: Ek – ident: 10.1016/j.ejps.2004.03.012_BIB6 – volume: 28 start-page: 117 year: 1990 ident: 10.1016/j.ejps.2004.03.012_BIB10 article-title: Stability of cannabioids in dried samples of cannabis dating from around 1896–1905 publication-title: J. Ethnopharm. doi: 10.1016/0378-8741(90)90068-5 contributor: fullname: Harvey – volume: 260 start-page: 1575 year: 1988 ident: 10.1016/j.ejps.2004.03.012_BIB8 article-title: Minimal contact treatment for smoking cessation. A placebo controlled trial of nicotine polacrilex and self-directed relapse prevention: initial results of the Stanford Stop Smoking Project publication-title: JAMA doi: 10.1001/jama.260.11.1575 contributor: fullname: Fortmann – volume: 52 start-page: 495 year: 1997 ident: 10.1016/j.ejps.2004.03.012_BIB13 article-title: Temperature dependency of the release and bioavailability of nicotine from a nicotine vapour inhaler; in vitro/in vivo correlation publication-title: Eur. J. Pharmacol. doi: 10.1007/s002280050324 contributor: fullname: Lunell – volume: 47 start-page: 225 year: 1999 ident: 10.1016/j.ejps.2004.03.012_BIB21 article-title: Effect of crystallinity of microcrystalline cellulose on the compactability and dissolution of tablets publication-title: Eur. J. Pharm. Biopharm. doi: 10.1016/S0939-6411(98)00102-7 contributor: fullname: Suzuki – volume: 5 start-page: 343 year: 1982 ident: 10.1016/j.ejps.2004.03.012_BIB7 article-title: A comparison of physiological and pharmacological treatment in smoking cessation publication-title: J. Behav. Med. doi: 10.1007/BF00846161 contributor: fullname: Fagerström – volume: 269 start-page: 433 issue: 2 year: 2004 ident: 10.1016/j.ejps.2004.03.012_BIB15 article-title: Moisture sorption by cellulose powders of varying crystallinity publication-title: Int. J. Pharm. doi: 10.1016/j.ijpharm.2003.09.030 contributor: fullname: Mihranyan – volume: 52 start-page: 265 issue: Feb 1 year: 1995 ident: 10.1016/j.ejps.2004.03.012_BIB11 article-title: Treatment of nicotine dependence publication-title: Am. J. Health-Syst. Pharm. doi: 10.1093/ajhp/52.3.265 contributor: fullname: Haxby – ident: 10.1016/j.ejps.2004.03.012_BIB5 – ident: 10.1016/j.ejps.2004.03.012_BIB17 doi: 10.1177/004051756503500605 – ident: 10.1016/j.ejps.2004.03.012_BIB9 – ident: 10.1016/j.ejps.2004.03.012_BIB18 doi: 10.1177/004051755902901003 – volume: 17 start-page: 1 issue: 1 year: 1997 ident: 10.1016/j.ejps.2004.03.012_BIB2 article-title: Cancer, cigarette smoking and premature death in Europe: a review including the recommendations of European Cancer Experts Consensus Meeting, Helsinki, October 1996 publication-title: Lung Cancer doi: 10.1016/S0169-5002(97)00648-X contributor: fullname: Boyle – ident: 10.1016/j.ejps.2004.03.012_BIB23 – ident: 10.1016/j.ejps.2004.03.012_BIB1 doi: 10.1016/B978-044450095-3/50006-1 – volume: 11 start-page: 263 year: 1998 ident: 10.1016/j.ejps.2004.03.012_BIB4 article-title: Cellulose powders from Cladophora sp. algae publication-title: J. Mol. Recogn. doi: 10.1002/(SICI)1099-1352(199812)11:1/6<263::AID-JMR437>3.0.CO;2-G contributor: fullname: Ek – volume: 81 start-page: 540 year: 1998 ident: 10.1016/j.ejps.2004.03.012_BIB16 article-title: In vitro study of nicotine release from smokeless tobacco publication-title: J. AOAC Int. doi: 10.1093/jaoac/81.3.540 contributor: fullname: Nasr – ident: 10.1016/j.ejps.2004.03.012_BIB24 doi: 10.1159/000062069 – volume: 48 start-page: 494 year: 1965 ident: 10.1016/j.ejps.2004.03.012_BIB25 article-title: Swellability of pulps determined by isopropanol retention publication-title: Tappi contributor: fullname: Yiannos – volume: 261 start-page: 63 year: 1988 ident: 10.1016/j.ejps.2004.03.012_BIB19 article-title: Nicotine replacement: the role of blood nicotine levels, their rate of change, and nicotine tolerance publication-title: Prog. Clin. Biol. Res. contributor: fullname: Russel
SSID	ssj0006870
Score	1.9961386
Snippet	The purpose of this study was to investigate the influence of the crystallinity, surface area, and pore volume of cellulose powders on the loading, release,...
SourceID	swepub proquest crossref pubmed pascalfrancis elsevier
SourceType	Open Access Repository Aggregation Database Index Database Publisher
StartPage	279
SubjectTerms	Adsorption Air Biological and medical sciences Cellulose Cellulose - chemistry Chemistry, Pharmaceutical - methods Cladophora sp. algae Crystallinity Crystallography General pharmacology Medical sciences Microcrystalline cellulose Microscopy, Electron, Scanning Nicotine Nicotine - chemistry Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Pore volume Powders Surface Properties
Title	Sorption of nicotine to cellulose powders
URI	https://dx.doi.org/10.1016/j.ejps.2004.03.012 https://www.ncbi.nlm.nih.gov/pubmed/15196584 https://search.proquest.com/docview/72025471 https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-67538
Volume	22
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
link	http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1La9wwEB6SzaVQQt912m51CIHSuGvLL-1xyYNtS0Mg25KbkK1R2RBss2sTculv78iys01pe-jVtpD4Pmk0Y2a-AdhXqdKc3Ggfk3Tqx1hoX0VTIoTOldBJzs3UFjh_OUvnX-NPl8nlFhwNtTA2rbK3_c6md9a6fzLp0ZzUy-XkIphyEVDIbLehFaXZhh26jrgYwc7s4-f52Z1BTkXXM85-79sBfe2MS_PCq7pT7Y47rdOQ_-1-elirNaFmXLuLP_mjv4mNdhfU6SPY7T1LNnOLfwxbWD6Bg3MnTX17yBabSqv1ITtg5xvR6tun8O6iWnXWg1WGlbQ9GnI_WVMx-2e_va7WyOrqxmY9P4PF6cniaO73bRT8Ig5F45sgVxTFFSYkvkySF5nALMeEo6JYUATKKGPPcZ4nmsIljlhEaChuKkyBSkXPYVRWJb4ElnEVYapFoDOMQ6NEodEEYa6M1iYOAw_eD9jJ2ollyCGL7EpapG3Xy1gGkSSkPUgGeOU9yiVZ83-OG9_jYjNVQs4XeRwevB3IkXRYLE6qxKpdy4zb4v8s9OCF4-yXsVZaUcQe7DsS795Y_e3j5beZrFbfZdtKirAisfefa38FD1zqj833fQ2jZtXiG_JqmnwM2x9-hON-7_4EOif4kA
link.rule.ids	230,315,783,787,888,4509,24128,27936,27937,45597,45691
linkProvider	Elsevier
linkToHtml	http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LT9wwEB5ROLQSqkqfKS34gJCqkm4eTuI9IgratoCQ2FbcLCceV4tQEu0mqrj0tzOOk26pKAeuia1Y8_I30cw3ADsqVToiGO1jko59joX2VTwmhZBfCZ3kkRnbBueT03TynX-9SC5W4GDohbFllX3sdzG9i9b9k1EvzVE9m43Og3EkAkqZrRlaUppHsMYtPiaj_vR7WeeRim5inF3t2-V954wr8sLLuuPs5h3TaRj973Zar9WCZGbcsIu70Og_VKPd9XT0DJ72uJLtu6NvwAqWz2H3zBFTX--x6bLParHHdtnZkrL6-gV8OK_mXexglWElGUdD4JM1FbP_9duraoGsrn7ZmueXMD06nB5M_H6Igl_wUDS-CXJFOVxhQtKWSfIiE5jlmESoKBMUgTLKWC_O80RTshQhFjEaypoKU6BS8StYLasS3wDLIhVjqkWgM-ShUaLQaIIwV0Zrw8PAg4-D7GTtqDLkUEN2Ka2k7cxLLoNYkqQ9SAbxylsKlxTL7923dUsXy08lBL0Ib3iwPShHkqtYOakSq3Yhs8i2_mehB6-dzv7aa4kVBfdgxynxzxvLvv159mNfVvOfsm0l5VexePvAs2_D48n05Fgefzn9tglPXBGQrfx9B6vNvMX3hG-afKuz3xt_Fflp
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Sorption+of+nicotine+to+cellulose+powders&rft.jtitle=European+journal+of+pharmaceutical+sciences&rft.au=Mihranyan%2C+Albert&rft.au=Andersson%2C+Sven-B%C3%B6rje&rft.au=Ek%2C+Ragnar&rft.date=2004-07-01&rft.pub=Elsevier+B.V&rft.issn=0928-0987&rft.eissn=1879-0720&rft.volume=22&rft.issue=4&rft.spage=279&rft.epage=286&rft_id=info:doi/10.1016%2Fj.ejps.2004.03.012&rft.externalDocID=S0928098704000776
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0928-0987&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0928-0987&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0928-0987&client=summon