Genetic Susceptibility to Enteroaggregative Escherichia coli Diarrhea: Polymorphism in the Interleukin-8 Promotor Region

• Published in: The Journal of infectious diseases Vol. 188; no. 4; pp. 506 - 511
• Main Authors: Jiang, Zhi-Dong, Okhuysen, Pablo C., Guo, Dong-Chuan, He, Rumin, King, Terri M., DuPont, Herbert L., Milewicz, Dianna M.
• Format: Journal Article
• Language: English
• Published: Chicago, IL The University of Chicago Press 15.08.2003; University of Chicago Press; Oxford University Press
• Subjects: Bacteria; Bacteriology; Biological and medical sciences; Diarrhea; Diarrhea - complications; Diarrhea - genetics; Diarrhea - microbiology; DNA; Escherichia coli; Escherichia coli - isolation & purification; Escherichia coli Infections - complications; Escherichia coli Infections - genetics; Feces - chemistry; Fundamental and applied biological sciences. Psychology; Genetic Predisposition to Disease; Genotype; Genotypes; Haplotypes; Humans; Infections; Interleukin-8 - analysis; Interleukin-8 - genetics; Interleukins; Mexico; Microbiology; Neutrophils; Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains; Pathogens; Polymorphism, Single Nucleotide - genetics; Students; Travel; Travelers; United States - ethnology; United States; Mexico; Transcription promoter; Escherichia coli; Diarrhea; Host agent relation; Infection; Sensitivity; Bacteriosis; Digestive diseases; Bacteria; Intestinal disease; Interleukin 8; Enterobacteriaceae; Polymorphism

Enteroaggregative Escherichia coli (EAEC) infection can be identified in 26% of travelers with diarrhea and is associated with fecal interleukin (IL)–8 production. We hypothesized that single-nucleotide polymorphisms (SNPs) in the IL-8 gene are associated with EAEC-related symptoms. Fecal IL-8 produ...