Estimation of Mouse Carotid Arterial Wall Shear Stress Using High-Frequency Ultrasound Imaging

• Published in: IEEE transactions on ultrasonics, ferroelectrics, and frequency control Vol. 70; no. 6; pp. 474 - 485
• Main Authors: Huang, Yu-Hsiang, Huang, Hsin, Mo, Fan-E, Huang, Chih-Chung
• Format: Journal Article
• Language: English
• Published: United States IEEE 01.06.2023; The Institute of Electrical and Electronics Engineers, Inc. (IEEE)
• Subjects: Animals; Apolipoproteins E; Arteries; Atherosclerosis; Atherosclerosis - diagnostic imaging; Atherosclerotic plaque; Blood flow; Blood Flow Velocity; Carotid arteries; Carotid Arteries - pathology; Doppler effect; Doppler flow imaging; Estimation; Flow characteristics; Flow velocity; Hemodynamics; high-frequency ultrasound (HFUS) imaging; Histology; Imaging; Mice; Mice, Inbred C57BL; Plaque, Atherosclerotic; Shear Strength; Shear stress; small animal imaging; Steady flow; Stress, Mechanical; Ultrasonic imaging; Ultrasonography, Doppler; Velocity gradient; Velocity measurement; wall shear stress (WSS); Wall shear stresses

Wall shear stress (WSS) is a crucial hemodynamic factor that promotes atherosclerosis (plaque) development in arteries; although the relationship between WSS and arterial atherosclerosis has been explored in many animal studies, it is not fully understood. No suitable tool, however, exists for rapid...