Oligoadenylate synthetase 1 displays dual antiviral mechanisms in driving translational shutdown and protecting interferon production

• Published in: Immunity (Cambridge, Mass.) Vol. 57; no. 3; pp. 446 - 461.e7
• Main Authors: Harioudh, Munesh K., Perez, Joseph, Chong, Zhenlu, Nair, Sharmila, So, Lomon, McCormick, Kevin D., Ghosh, Arundhati, Shao, Lulu, Srivastava, Rashmi, Soveg, Frank, Ebert, Thomas S., Atianand, Maninjay K., Hornung, Veit, Savan, Ram, Diamond, Michael S., Sarkar, Saumendra N.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 12.03.2024
• Subjects: 2',5'-Oligoadenylate Synthetase - genetics; 2',5'-Oligoadenylate Synthetase - metabolism; Adenine Nucleotides; Animals; Antiviral Agents - pharmacology; antiviral mechanism; Humans; interferon; interferon-stimulated genes; Interferons; Mice; oligoadenylate synthetase; Oligoribonucleotides; SARS-CoV-2; Virus Diseases; West Nile Fever - genetics; West Nile Fever - metabolism; West Nile virus; West Nile virus - metabolism; West Nile virus - pathogenicity; SARS-CoV-2; interferon-stimulated genes; oligoadenylate synthetase; interferon; antiviral mechanism; West Nile virus

In response to viral infection, how cells balance translational shutdown to limit viral replication and the induction of antiviral components like interferons (IFNs) is not well understood. Moreover, how distinct isoforms of IFN-induced oligoadenylate synthetase 1 (OAS1) contribute to this antiviral...