Platelet derived growth factor (PDGF)-induced reactive oxygen species in the lens epithelial cells: the redox signaling

• Published in: Experimental eye research Vol. 78; no. 6; pp. 1057 - 1067
• Main Authors: Chao-Wei Chen, Kate, Zhou, You, Xing, Kuiyi, Krysan, Kostantyn, Lou, Marjorie F.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.06.2004
• Subjects: Antioxidants - pharmacology; Catalase - metabolism; Catalase - pharmacology; Cell Division - drug effects; cell proliferation; Cells, Cultured; EGF; Epithelial Cells - drug effects; Epithelial Cells - metabolism; growth factors; Humans; Hydrogen Peroxide - pharmacology; JNK; Lens, Crystalline - drug effects; Lens, Crystalline - metabolism; Mannitol - pharmacology; MAPkinase; Microscopy, Confocal; Microscopy, Fluorescence; Mitogen-Activated Protein Kinases - metabolism; Oxidation-Reduction - drug effects; p38; PDGF; phosphorylation; Platelet-Derived Growth Factor - antagonists & inhibitors; Platelet-Derived Growth Factor - pharmacology; reactive oxygen species (ROS); Reactive Oxygen Species - metabolism; redox signaling; Signal Transduction; redox signaling; p38; growth factors; cell proliferation; signal transduction; EGF; JNK; PDGF; MAPkinase; reactive oxygen species (ROS); phosphorylation

Low level of reactive oxygen species (ROS) has been shown to play an important role in host defense and mediating mitogen-stimulated cell signaling in several cell types. This study is to identify the mitogen-induced endogenous ROS generation and the range of exogenous H 2O 2 that initiate redox sig...