The Role of Phospholipid Methylation in 1-Methyl-4-Phenyl-Pyridinium Ion (MPP +)-Induced Neurotoxicity in PC12 Cells

• Published in: Neurotoxicology (Park Forest South) Vol. 26; no. 6; pp. 945 - 957
• Main Authors: Lee, Eun-Sook Y., Chen, Hongtao, Charlton, Clivel G., Soliman, Karam F.A.
• Format: Journal Article
• Language: English
• Published: Orlando, FL Elsevier B.V 01.12.2005; Elsevier
• Subjects: 1-Methyl-4-phenylpyridinium; Animals; Biological and medical sciences; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Dopamine - metabolism; Lysophosphatidylcholine; Lysophosphatidylcholines - biosynthesis; Lysophosphatidylcholines - metabolism; Medical sciences; Methylation - drug effects; MPP; MPTP Poisoning - metabolism; Nervous system (semeiology, syndromes); Nervous system as a whole; Neurology; Parkinson's disease; PC12 Cells; Phosphatidylcholines - biosynthesis; Phosphatidylethanolamine N-Methyltransferase - drug effects; Phosphatidylethanolamine N-Methyltransferase - metabolism; Phosphatidylethanolamines - metabolism; Phospholipid methylation; Phospholipids - metabolism; Rats; S-Adenosylhomocysteine - pharmacology; S-Adenosylmethionine; S-Adenosylmethionine - pharmacology; Toxicology; Phospholipid methylation; Parkinson's disease; MPP; PC12 cells; Lysophosphatidylcholine; S-Adenosylmethionine; Nervous system diseases; Adenosylmethionine; Toxicity; Parkinson disease; Phospholipid; Lipids; Cerebral disorder; Central nervous system disease; Degenerative disease; Methylation; Extrapyramidal syndrome

Excessive methylation has been proposed to be involved in the pathogenesis of Parkinson's disease (PD), via mechanisms that involve phospholipid methylation. Meanwhile, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) was found to stimulate phospholipid methylation via the oxidized metabolit...