Surface profiles for subclassification of chronic lymphocytic leukemia

• Published in: Leukemia & lymphoma Vol. 53; no. 6; pp. 1046 - 1056
• Main Authors: Huang, Pauline Y., Best, O. Giles, Belov, Larissa, Mulligan, Stephen P., Christopherson, Richard I.
• Format: Journal Article
• Language: English
• Published: United States Informa Healthcare 01.06.2012; Taylor & Francis
• Subjects: antibodies; Antigens, CD - genetics; Antigens, CD - metabolism; Antigens, Surface - genetics; Antigens, Surface - metabolism; Biomarkers, Tumor - genetics; Biomarkers, Tumor - metabolism; CD antigens; Chronic lymphocytic leukemia; Disease Progression; Gene Expression Profiling; Humans; immunophenotype; Leukemia, Lymphocytic, Chronic, B-Cell - classification; Leukemia, Lymphocytic, Chronic, B-Cell - diagnosis; Leukemia, Lymphocytic, Chronic, B-Cell - genetics; Leukemia, Lymphocytic, Chronic, B-Cell - pathology; microarray; Microarray Analysis; Models, Biological; Neoplasm Staging - methods; Prognosis

Chronic lymphocytic leukemia (CLL) has a variable clinical course. Some patients have stable disease while others progress and require treatment. Levels of several cluster of differentiation (CD) antigens are known to correlate with prognosis and may be used to stratify patients according to risk. I...