Surface profiles for subclassification of chronic lymphocytic leukemia

Chronic lymphocytic leukemia (CLL) has a variable clinical course. Some patients have stable disease while others progress and require treatment. Levels of several cluster of differentiation (CD) antigens are known to correlate with prognosis and may be used to stratify patients according to risk. I...

Full description

Saved in:
Bibliographic Details
Published inLeukemia & lymphoma Vol. 53; no. 6; pp. 1046 - 1056
Main Authors Huang, Pauline Y., Best, O. Giles, Belov, Larissa, Mulligan, Stephen P., Christopherson, Richard I.
Format Journal Article
LanguageEnglish
Published United States Informa Healthcare 01.06.2012
Taylor & Francis
Subjects
antibodies
Antigens, CD - genetics
Antigens, CD - metabolism
Antigens, Surface - genetics
Antigens, Surface - metabolism
Biomarkers, Tumor - genetics
Biomarkers, Tumor - metabolism
CD antigens
Chronic lymphocytic leukemia
Disease Progression
Gene Expression Profiling
Humans
immunophenotype
Leukemia, Lymphocytic, Chronic, B-Cell - classification
Leukemia, Lymphocytic, Chronic, B-Cell - diagnosis
Leukemia, Lymphocytic, Chronic, B-Cell - genetics
Leukemia, Lymphocytic, Chronic, B-Cell - pathology
microarray
Microarray Analysis
Models, Biological
Neoplasm Staging - methods
Prognosis
Online AccessGet full text

Cover

Abstract Chronic lymphocytic leukemia (CLL) has a variable clinical course. Some patients have stable disease while others progress and require treatment. Levels of several cluster of differentiation (CD) antigens are known to correlate with prognosis and may be used to stratify patients according to risk. In this review, we summarize current information on surface CD antigens found on CLL, their pathological significance and their detection using CD antibody microarrays. The use of extensive immunophenotypic patterns or surface profiles as disease signatures for CLL subclassification, prognosis and patient management is discussed with a focus on triaging patients with CLL with progressive disease.
AbstractList Chronic lymphocytic leukemia (CLL) has a variable clinical course. Some patients have stable disease while others progress and require treatment. Levels of several cluster of differentiation (CD) antigens are known to correlate with prognosis and may be used to stratify patients according to risk. In this review, we summarize current information on surface CD antigens found on CLL, their pathological significance and their detection using CD antibody microarrays. The use of extensive immunophenotypic patterns or surface profiles as disease signatures for CLL subclassification, prognosis and patient management is discussed with a focus on triaging patients with CLL with progressive disease.
Author Christopherson, Richard I.
Huang, Pauline Y.
Best, O. Giles
Belov, Larissa
Mulligan, Stephen P.
Author_xml – sequence: 1
  givenname: Pauline Y.
  surname: Huang
  fullname: Huang, Pauline Y.
  email: richard.christopherson@sydney.edu.au, richard.christopherson@sydney.edu.au
  organization: School of Molecular Bioscience, University of Sydney
– sequence: 2
  givenname: O. Giles
  surname: Best
  fullname: Best, O. Giles
  email: richard.christopherson@sydney.edu.au, richard.christopherson@sydney.edu.au
  organization: Northern Blood Research Centre, Kolling Institute of Medical Research, Royal North Shore Hospital
– sequence: 3
  givenname: Larissa
  surname: Belov
  fullname: Belov, Larissa
  email: richard.christopherson@sydney.edu.au, richard.christopherson@sydney.edu.au
  organization: School of Molecular Bioscience, University of Sydney
– sequence: 4
  givenname: Stephen P.
  surname: Mulligan
  fullname: Mulligan, Stephen P.
  email: richard.christopherson@sydney.edu.au, richard.christopherson@sydney.edu.au
  organization: School of Molecular Bioscience, University of Sydney
– sequence: 5
  givenname: Richard I.
  surname: Christopherson
  fullname: Christopherson, Richard I.
  email: richard.christopherson@sydney.edu.au, richard.christopherson@sydney.edu.au
  organization: School of Molecular Bioscience, University of Sydney
BackLink https://www.ncbi.nlm.nih.gov/pubmed/22023531$$D View this record in MEDLINE/PubMed
BookMark eNp9kE1P3DAQhq2KqrC0_6CqcuSSxR5_4FyK0KoUpJU4tD1bjjPWmjrx1k6E9t-TaKESF04zh-d9Z_SsyMmQBiTkK6NrzmhzyagAzRqxBsrYWnHGr-gHcsYoNDUIyk-WXUC9MKdkVcojpVQ2Cj6RUwAKXHJ2Rm5_Tdlbh9U-Jx8ilsqnXJWpddGWEnxwdgxpqJKv3C6nIbgqHvr9LrnDuOw4_cU-2M_ko7ex4JeXeU7-3P74vbmrtw8_7zc329oJpsfaAYMrgeAtg1ZqjUp2WrpW-Ra1dSB4owRaBOkkArROKFCy1brpkNO24-fk4tg7v_tvwjKaPhSHMdoB01QMo0wKpTRvZlQcUZdTKRm92efQ23yYIbMYNK8GzWLQHA3OsW8vF6a2x-5_6FXZDFwfgTDMqnr7lHLszGgPMWWf7eBCWerfPfH9TcMObRx3zmY0j2nKwyzw_R-fAVUolTQ
CitedBy_id crossref_primary_10_1016_j_jprot_2017_01_001
crossref_primary_10_1002_stem_2051
crossref_primary_10_3390_ijms140611034
crossref_primary_10_1007_s00580_018_2671_z
crossref_primary_10_1111_ijlh_12054
crossref_primary_10_3109_10428194_2013_867486
crossref_primary_10_1002_prca_201300048
crossref_primary_10_1002_cyto_b_21722
Cites_doi 10.1080/1042819021000054689
10.1309/1TYF-VPM9-CQ2C-B0TF
10.1189/jlb.71.3.495
10.1046/j.0007-1048.2001.3205.x
10.1111/j.1749-6632.1995.tb26651.x
10.1002/hon.888
10.1016/j.leukres.2008.08.021
10.3109/10428190109097682
10.1182/blood.V95.4.1199.004k21_1199_1206
10.1056/NEJM200012283432602
10.1309/AJCPQS4OXJJSZ5KN
10.1038/sj.leu.2403294
10.1046/j.1365-2141.1998.00928.x
10.1038/sj.leu.2400874
10.1038/sj.thj.6200360
10.1034/j.1600-065X.2002.18611.x
10.1046/j.1365-2141.2003.04213.x
10.1182/blood.V62.2.256.256
10.1182/blood-2002-06-1801
10.1016/j.leukres.2010.10.022
10.1016/j.leukres.2005.11.019
10.1182/blood.V94.6.1840
10.1002/ajh.20987
10.1186/1479-5876-4-11
10.1038/sj.leu.2402339
10.1034/j.1600-0609.2002.01515.x
10.1111/j.1365-2141.1992.tb08169.x
10.1046/j.1365-2141.2002.03673.x
10.1182/blood-2007-06-094029
10.1002/hon.877
10.1016/0165-2478(94)00230-O
10.1016/j.leukres.2008.09.001
10.1016/j.jim.2005.07.004
10.1002/cyto.b.20390
10.3109/10428199109103374
10.1016/j.leukres.2009.07.032
10.1016/S0140-6736(03)15260-9
10.1309/4AGUT3LKEURD7T7K
10.1002/(SICI)1096-8652(199607)52:3<224::AID-AJH17>3.0.CO;2-F
10.1182/blood-2002-07-2249
10.1111/j.1600-0609.2009.01287.x
10.1016/j.beha.2010.01.006
10.1016/j.clim.2009.02.004
10.1016/S1074-7613(00)80530-0
10.1111/j.1365-2141.2009.07965.x
10.1016/j.leukres.2008.06.026
10.1002/1097-0142(197708)40:2<855::AID-CNCR2820400239>3.0.CO;2-1
10.1007/s00115-002-1314-3
10.1111/j.1365-2141.1981.tb07274.x
10.1002/cyto.b.20423
10.1182/blood-2002-09-2906
10.1038/sj.leu.2401275
10.1002/jcp.20269
10.3109/10428194.2010.503820
10.1172/JCI24387
10.5858/2000-124-1361-CEOBCI
10.1002/ajh.2830460304
10.1084/jem.153.1.207
10.1038/35080033
10.1038/sj.leu.2402363
10.2353/jmoldx.2010.090100
10.1002/1097-0142(19810701)48:1<198::AID-CNCR2820480131>3.0.CO;2-V
10.1038/sj.leu.2403707
10.1309/AJCPNCOHS92ARWRQ
10.1084/jem.190.3.301
10.1182/blood.V73.4.1000.1000
10.1046/j.1365-3083.2001.00984.x
10.1111/j.1445-5994.2009.02135.x
10.1016/S1471-4906(02)02223-8
10.1080/10428190410001683697
10.1080/10245330400020470
10.1182/blood.V100.4.1110b
10.3324/haematol.13103
10.1182/blood-2007-05-092486
10.1080/17843286.1994.11718386
10.1182/blood-2003-03-0989
10.1034/j.1600-065X.2003.00067.x
10.1532/LH96.08015
10.1182/blood.V82.4.1239.1239
10.1182/blood-2006-03-010553
10.1182/blood-2004-08-3335
10.1182/blood-2002-10-3306
10.3324/haematol.11646
10.1002/pmic.200300599
10.1182/blood-2007-08-108605
10.1111/j.1365-2141.2011.08794.x
10.1016/S0165-4608(96)00249-X
10.1056/NEJMoa023143
10.1002/ajh.20936
10.1038/leu.2008.21
10.1016/j.leukres.2010.10.002
10.1080/10428190600947776
10.1159/000089470
10.1016/S1074-7613(00)80165-X
10.1182/blood.V98.3.814
10.1038/sj.leu.2404935
10.1097/01.TP.0000152118.51622.F9
10.1002/cyto.990180109
10.1309/V8YG-8PP4-B4TE-9X6J
10.1182/blood.V94.6.1848
10.2478/v10042-008-0022-7
10.1016/S0198-8859(00)00197-X
10.1371/journal.pone.0016956
10.3892/or_00000924
10.1182/blood.V46.2.219.219
10.1111/j.1365-2141.2006.06266.x
10.1111/j.1365-2141.2009.07703.x
10.1016/j.beha.2010.01.001
10.1016/j.beha.2009.12.003
10.1093/annonc/mdj120
10.1182/blood.V99.11.4087
10.1179/102453309X385197
10.1182/blood-2007-05-092882
10.1182/blood-2006-01-013003
10.1182/blood-2007-05-089409
10.1002/cyto.10131
10.1038/sj.leu.2404559
10.1189/jlb.1009686
10.1182/blood.V98.1.181
10.1111/j.1365-2141.2007.06965.x
10.1002/(SICI)1097-0215(19970106)70:1<1::AID-IJC1>3.0.CO;2-1
10.1182/blood-2006-11-054916
10.1182/blood-2009-12-257758
10.1111/j.1365-2141.2005.05659.x
10.1002/jcp.20570
ContentType Journal Article
Copyright 2012 Informa UK, Ltd. 2012
Copyright_xml – notice: 2012 Informa UK, Ltd. 2012
DBID CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
7X8
DOI 10.3109/10428194.2011.631370
DatabaseName Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
MEDLINE - Academic
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
MEDLINE - Academic
DatabaseTitleList
MEDLINE - Academic
MEDLINE
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
EISSN 1029-2403
EndPage 1056
ExternalDocumentID 10_3109_10428194_2011_631370
22023531
631370
Genre Review Articles
Research Support, Non-U.S. Gov't
Journal Article
Review
GroupedDBID ---
00X
03L
0BK
0R~
29L
36B
4.4
53G
5GY
5VS
AAJNR
AALIY
AALUX
AAMIU
AAPUL
AAPXX
AAQRR
ABBKH
ABDBF
ABEIZ
ABLKL
ABPTK
ABUPF
ABWCV
ABZEW
ACENM
ACFUF
ACGEJ
ACGFS
ACKZS
ACLSK
ADCVX
ADFCX
ADFOM
ADFZZ
ADRBQ
ADXPE
AECIN
AEIIZ
AENEX
AEOZL
AEXWM
AEYQI
AFKVX
AFLEI
AFWLO
AGDLA
AGFJD
AGRBW
AGYJP
AIJEM
AIRBT
AJVHN
AJWEG
AKBVH
ALIIL
ALMA_UNASSIGNED_HOLDINGS
ALQZU
AMDAE
AWYRJ
BABNJ
BLEHA
BOHLJ
BRMBE
CAG
CCCUG
COF
CS3
CYYVM
CZDIS
DKSSO
DRXRE
DU5
DWTOO
EAP
EBB
EBC
EBD
EBS
EBX
EJD
EMB
EMK
EMOBN
EPL
ESX
F5P
H13
HF~
HZ~
J.N
JENTW
KRBQP
KSSTO
KWAYT
KYCEM
LGLTD
LJTGL
M44
M4Z
O9-
P2P
QQXMO
RNANH
RVRKI
SV3
TFDNU
TFL
TFW
TUS
UDS
UEQFS
V1S
Y6R
ZGI
ZXP
~1N
AAORF
ABLIJ
ABXYU
ACIEZ
ALYBC
CGR
CUY
CVF
ECM
EIF
NPM
NUSFT
TBQAZ
TDBHL
TERGH
TUROJ
AAYXX
CITATION
7X8
ID FETCH-LOGICAL-c418t-c21274e2fa12b588e65d85cb6fbe8ac243964eae25c5e22bc46265b889de30bd3
ISSN 1042-8194
IngestDate Fri Oct 25 09:35:52 EDT 2024
Fri Dec 06 04:32:03 EST 2024
Wed Oct 16 00:53:37 EDT 2024
Tue Jul 04 18:18:34 EDT 2023
Wed Jun 21 01:44:19 EDT 2023
IsPeerReviewed true
IsScholarly true
Issue 6
Language English
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-c418t-c21274e2fa12b588e65d85cb6fbe8ac243964eae25c5e22bc46265b889de30bd3
Notes ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
PMID 22023531
PQID 1015466839
PQPubID 23479
PageCount 11
ParticipantIDs informahealthcare_journals_10_3109_10428194_2011_631370
proquest_miscellaneous_1015466839
pubmed_primary_22023531
crossref_primary_10_3109_10428194_2011_631370
informaworld_taylorfrancis_310_3109_10428194_2011_631370
PublicationCentury 2000
PublicationDate 20120600
6/1/2012
2012-Jun
2012-06-01
20120601
PublicationDateYYYYMMDD 2012-06-01
PublicationDate_xml – month: 06
  year: 2012
  text: 20120600
PublicationDecade 2010
PublicationPlace United States
PublicationPlace_xml – name: United States
PublicationTitle Leukemia & lymphoma
PublicationTitleAlternate Leuk Lymphoma
PublicationYear 2012
Publisher Informa Healthcare
Taylor & Francis
Publisher_xml – name: Informa Healthcare
– name: Taylor & Francis
References CIT0072
CIT0074
CIT0073
CIT0076
CIT0075
Brunet C (CIT0078) 1998; 40
CIT0111
CIT0110
CIT0070
Islam A (CIT0071) 2000; 124
CIT0113
CIT0079
CIT0112
CIT0115
CIT0117
CIT0116
CIT0119
Kipps T (CIT0099) 1995
CIT0118
CIT0083
CIT0082
CIT0085
CIT0084
Pro B (CIT0053) 2004; 19
CIT0087
CIT0120
CIT0086
Zupo S (CIT0100) 2000; 95
CIT0001
CIT0089
CIT0122
CIT0088
CIT0121
CIT0081
CIT0080
CIT0003
CIT0002
CIT0005
CIT0126
CIT0004
CIT0125
CIT0007
CIT0128
CIT0006
CIT0127
CIT0009
CIT0008
CIT0129
CIT0094
Uckun FM (CIT0058) 1989; 73
CIT0093
CIT0096
CIT0095
CIT0010
CIT0098
CIT0131
CIT0097
CIT0012
CIT0133
CIT0011
CIT0132
CIT0090
Matutes E (CIT0013) 1994; 8
CIT0092
CIT0091
CIT0014
CIT0135
CIT0134
CIT0016
CIT0137
CIT0015
Attadia V (CIT0077) 1996; 10
CIT0136
CIT0018
CIT0139
CIT0017
Penna G (CIT0123) 2010
CIT0138
Del Principe MI (CIT0130) 2004; 89
CIT0019
CIT0021
CIT0020
CIT0023
CIT0022
Cantu-Rajnoldi A (CIT0056) 1992; 77
de la Fuente MT (CIT0035) 2002; 71
Sulda ML (CIT0047) 2010
CIT0025
CIT0027
CIT0026
CIT0029
CIT0028
CIT0030
CIT0032
CIT0031
CIT0034
CIT0033
CIT0038
CIT0037
CIT0039
CIT0041
CIT0040
CIT0043
CIT0042
CIT0045
CIT0044
Eksioglu-Demiralp E (CIT0036) 1996; 10
CIT0049
CIT0048
CIT0050
CIT0052
CIT0051
CIT0054
Ligler FS (CIT0104) 1983; 62
CIT0055
Newman RA (CIT0065) 1993; 82
Burton J (CIT0046) 1994; 8
Hjalmar V (CIT0114) 1998; 83
CIT0057
Zhu HJ (CIT0124) 2010; 18
CIT0059
CIT0061
CIT0060
CIT0063
CIT0062
CIT0064
CIT0067
CIT0066
CIT0109
Boonstra JG (CIT0024) 2004; 18
CIT0069
CIT0102
CIT0068
CIT0101
CIT0103
CIT0106
CIT0105
CIT0108
CIT0107
References_xml – ident: CIT0069
  doi: 10.1080/1042819021000054689
– ident: CIT0105
  doi: 10.1309/1TYF-VPM9-CQ2C-B0TF
– volume: 71
  start-page: 495
  year: 2002
  ident: CIT0035
  publication-title: J Leukoc Biol
  doi: 10.1189/jlb.71.3.495
  contributor:
    fullname: de la Fuente MT
– ident: CIT0018
  doi: 10.1046/j.0007-1048.2001.3205.x
– ident: CIT0101
  doi: 10.1111/j.1749-6632.1995.tb26651.x
– ident: CIT0054
  doi: 10.1002/hon.888
– ident: CIT0094
  doi: 10.1016/j.leukres.2008.08.021
– volume: 18
  start-page: 340
  year: 2004
  ident: CIT0024
  publication-title: J Biol Regul Homeost Agents
  contributor:
    fullname: Boonstra JG
– ident: CIT0019
  doi: 10.3109/10428190109097682
– volume: 95
  start-page: 1199
  year: 2000
  ident: CIT0100
  publication-title: Blood
  doi: 10.1182/blood.V95.4.1199.004k21_1199_1206
  contributor:
    fullname: Zupo S
– ident: CIT0108
  doi: 10.1056/NEJM200012283432602
– ident: CIT0126
  doi: 10.1309/AJCPQS4OXJJSZ5KN
– ident: CIT0084
  doi: 10.1038/sj.leu.2403294
– ident: CIT0073
  doi: 10.1046/j.1365-2141.1998.00928.x
– ident: CIT0070
  doi: 10.1038/sj.leu.2400874
– ident: CIT0128
  doi: 10.1038/sj.thj.6200360
– ident: CIT0033
  doi: 10.1034/j.1600-065X.2002.18611.x
– ident: CIT0129
  doi: 10.1046/j.1365-2141.2003.04213.x
– volume: 62
  start-page: 256
  year: 1983
  ident: CIT0104
  publication-title: Blood
  doi: 10.1182/blood.V62.2.256.256
  contributor:
    fullname: Ligler FS
– ident: CIT0021
  doi: 10.1182/blood-2002-06-1801
– ident: CIT0040
  doi: 10.1016/j.leukres.2010.10.022
– ident: CIT0048
  doi: 10.1016/j.leukres.2005.11.019
– ident: CIT0005
  doi: 10.1182/blood.V94.6.1840
– ident: CIT0134
  doi: 10.1002/ajh.20987
– ident: CIT0112
  doi: 10.1186/1479-5876-4-11
– ident: CIT0020
  doi: 10.1038/sj.leu.2402339
– volume: 10
  start-page: 1331
  year: 1996
  ident: CIT0036
  publication-title: Leukemia
  contributor:
    fullname: Eksioglu-Demiralp E
– ident: CIT0043
  doi: 10.1034/j.1600-0609.2002.01515.x
– ident: CIT0064
  doi: 10.1111/j.1365-2141.1992.tb08169.x
– ident: CIT0023
  doi: 10.1046/j.1365-2141.2002.03673.x
– start-page: 1017
  volume-title: William's hematology
  year: 1995
  ident: CIT0099
  contributor:
    fullname: Kipps T
– ident: CIT0031
  doi: 10.1182/blood-2007-06-094029
– ident: CIT0030
  doi: 10.1002/hon.877
– ident: CIT0051
  doi: 10.1016/0165-2478(94)00230-O
– ident: CIT0027
  doi: 10.1016/j.leukres.2008.09.001
– ident: CIT0113
  doi: 10.1016/j.jim.2005.07.004
– volume: 10
  start-page: 1544
  year: 1996
  ident: CIT0077
  publication-title: Leukemia
  contributor:
    fullname: Attadia V
– ident: CIT0109
  doi: 10.1002/cyto.b.20390
– ident: CIT0115
  doi: 10.3109/10428199109103374
– ident: CIT0120
  doi: 10.1016/j.leukres.2009.07.032
– ident: CIT0008
  doi: 10.1016/S0140-6736(03)15260-9
– ident: CIT0066
  doi: 10.1309/4AGUT3LKEURD7T7K
– ident: CIT0057
  doi: 10.1002/(SICI)1096-8652(199607)52:3<224::AID-AJH17>3.0.CO;2-F
– ident: CIT0026
  doi: 10.1182/blood-2002-07-2249
– ident: CIT0118
  doi: 10.1111/j.1600-0609.2009.01287.x
– ident: CIT0090
  doi: 10.1016/j.beha.2010.01.006
– ident: CIT0039
  doi: 10.1016/j.clim.2009.02.004
– ident: CIT0087
  doi: 10.1016/S1074-7613(00)80530-0
– ident: CIT0089
  doi: 10.1111/j.1365-2141.2009.07965.x
– ident: CIT0137
  doi: 10.1016/j.leukres.2008.06.026
– ident: CIT0003
  doi: 10.1002/1097-0142(197708)40:2<855::AID-CNCR2820400239>3.0.CO;2-1
– ident: CIT0041
  doi: 10.1007/s00115-002-1314-3
– volume: 77
  start-page: 384
  year: 1992
  ident: CIT0056
  publication-title: Haematologica
  contributor:
    fullname: Cantu-Rajnoldi A
– ident: CIT0063
  doi: 10.1111/j.1365-2141.1981.tb07274.x
– ident: CIT0059
  doi: 10.1002/cyto.b.20423
– ident: CIT0085
  doi: 10.1182/blood-2002-09-2906
– ident: CIT0034
  doi: 10.1038/sj.leu.2401275
– ident: CIT0049
  doi: 10.1002/jcp.20269
– ident: CIT0079
  doi: 10.3109/10428194.2010.503820
– ident: CIT0103
  doi: 10.1172/JCI24387
– volume: 124
  start-page: 1361
  year: 2000
  ident: CIT0071
  publication-title: Arch Pathol Lab Med
  doi: 10.5858/2000-124-1361-CEOBCI
  contributor:
    fullname: Islam A
– volume: 89
  start-page: 1468
  year: 2004
  ident: CIT0130
  publication-title: Haematologica
  contributor:
    fullname: Del Principe MI
– ident: CIT0044
  doi: 10.1002/ajh.2830460304
– ident: CIT0055
  doi: 10.1084/jem.153.1.207
– ident: CIT0083
  doi: 10.1038/35080033
– ident: CIT0110
  doi: 10.1038/sj.leu.2402363
– ident: CIT0121
  doi: 10.2353/jmoldx.2010.090100
– ident: CIT0004
  doi: 10.1002/1097-0142(19810701)48:1<198::AID-CNCR2820480131>3.0.CO;2-V
– ident: CIT0028
  doi: 10.1038/sj.leu.2403707
– ident: CIT0068
  doi: 10.1309/AJCPNCOHS92ARWRQ
– ident: CIT0052
  doi: 10.1084/jem.190.3.301
– volume: 73
  start-page: 1000
  year: 1989
  ident: CIT0058
  publication-title: Blood
  doi: 10.1182/blood.V73.4.1000.1000
  contributor:
    fullname: Uckun FM
– ident: CIT0050
  doi: 10.1046/j.1365-3083.2001.00984.x
– ident: CIT0139
  doi: 10.1111/j.1445-5994.2009.02135.x
– ident: CIT0091
  doi: 10.1016/S1471-4906(02)02223-8
– ident: CIT0075
  doi: 10.1080/10428190410001683697
– ident: CIT0025
  doi: 10.1080/10245330400020470
– ident: CIT0001
  doi: 10.1182/blood.V100.4.1110b
– ident: CIT0037
  doi: 10.3324/haematol.13103
– ident: CIT0038
  doi: 10.1182/blood-2007-05-092486
– ident: CIT0060
  doi: 10.1080/17843286.1994.11718386
– ident: CIT0016
  doi: 10.1182/blood-2003-03-0989
– volume: 8
  start-page: 92
  year: 1994
  ident: CIT0046
  publication-title: Leukemia
  contributor:
    fullname: Burton J
– ident: CIT0096
  doi: 10.1034/j.1600-065X.2003.00067.x
– ident: CIT0076
  doi: 10.1532/LH96.08015
– volume: 82
  start-page: 1239
  year: 1993
  ident: CIT0065
  publication-title: Blood
  doi: 10.1182/blood.V82.4.1239.1239
  contributor:
    fullname: Newman RA
– ident: CIT0029
  doi: 10.1182/blood-2006-03-010553
– ident: CIT0081
  doi: 10.1182/blood-2004-08-3335
– ident: CIT0009
  doi: 10.1182/blood-2002-10-3306
– ident: CIT0102
  doi: 10.3324/haematol.11646
– ident: CIT0012
  doi: 10.1002/pmic.200300599
– ident: CIT0032
  doi: 10.1182/blood-2007-08-108605
– ident: CIT0042
  doi: 10.1111/j.1365-2141.2011.08794.x
– ident: CIT0045
  doi: 10.1016/S0165-4608(96)00249-X
– ident: CIT0007
  doi: 10.1056/NEJMoa023143
– ident: CIT0132
  doi: 10.1002/ajh.20936
– ident: CIT0088
  doi: 10.1038/leu.2008.21
– ident: CIT0119
  doi: 10.1016/j.leukres.2010.10.002
– ident: CIT0011
  doi: 10.1080/10428190600947776
– ident: CIT0074
  doi: 10.1159/000089470
– ident: CIT0097
  doi: 10.1016/S1074-7613(00)80165-X
– volume: 19
  start-page: 1345
  year: 2004
  ident: CIT0053
  publication-title: Histol Histopathol
  contributor:
    fullname: Pro B
– ident: CIT0116
  doi: 10.1182/blood.V98.3.814
– ident: CIT0133
  doi: 10.1038/sj.leu.2404935
– ident: CIT0092
  doi: 10.1097/01.TP.0000152118.51622.F9
– ident: CIT0062
  doi: 10.1002/cyto.990180109
– ident: CIT0072
  doi: 10.1309/V8YG-8PP4-B4TE-9X6J
– volume: 40
  start-page: 279
  year: 1998
  ident: CIT0078
  publication-title: Hematol Cell Ther
  contributor:
    fullname: Brunet C
– ident: CIT0006
  doi: 10.1182/blood.V94.6.1848
– ident: CIT0135
  doi: 10.2478/v10042-008-0022-7
– ident: CIT0080
  doi: 10.1016/S0198-8859(00)00197-X
– ident: CIT0122
  doi: 10.1371/journal.pone.0016956
– ident: CIT0106
  doi: 10.3892/or_00000924
– ident: CIT0002
  doi: 10.1182/blood.V46.2.219.219
– ident: CIT0015
  doi: 10.1111/j.1365-2141.2006.06266.x
– ident: CIT0138
  doi: 10.1111/j.1365-2141.2009.07703.x
– ident: CIT0014
  doi: 10.1016/j.beha.2010.01.001
– volume: 83
  start-page: 602
  year: 1998
  ident: CIT0114
  publication-title: Haematologica
  contributor:
    fullname: Hjalmar V
– year: 2010
  ident: CIT0047
  publication-title: Intern Med J
  contributor:
    fullname: Sulda ML
– ident: CIT0117
  doi: 10.1016/j.beha.2009.12.003
– ident: CIT0131
  doi: 10.1093/annonc/mdj120
– ident: CIT0107
  doi: 10.1182/blood.V99.11.4087
– ident: CIT0082
  doi: 10.1179/102453309X385197
– ident: CIT0136
  doi: 10.1182/blood-2007-05-092882
– year: 2010
  ident: CIT0123
  publication-title: Med Oncol
  contributor:
    fullname: Penna G
– volume: 8
  start-page: 1640
  year: 1994
  ident: CIT0013
  publication-title: Leukemia
  contributor:
    fullname: Matutes E
– ident: CIT0017
  doi: 10.1182/blood-2006-01-013003
– ident: CIT0098
  doi: 10.1182/blood-2007-05-089409
– ident: CIT0061
  doi: 10.1002/cyto.10131
– ident: CIT0093
  doi: 10.1038/sj.leu.2404559
– ident: CIT0095
  doi: 10.1189/jlb.1009686
– ident: CIT0022
  doi: 10.1182/blood.V98.1.181
– volume: 18
  start-page: 843
  year: 2010
  ident: CIT0124
  publication-title: Zhongguo Shi Yan Xue Ye Xue Za Zhi
  contributor:
    fullname: Zhu HJ
– ident: CIT0010
  doi: 10.1111/j.1365-2141.2007.06965.x
– ident: CIT0067
  doi: 10.1002/(SICI)1097-0215(19970106)70:1<1::AID-IJC1>3.0.CO;2-1
– ident: CIT0125
  doi: 10.1182/blood-2006-11-054916
– ident: CIT0086
  doi: 10.1182/blood-2009-12-257758
– ident: CIT0127
  doi: 10.1111/j.1365-2141.2005.05659.x
– ident: CIT0111
  doi: 10.1002/jcp.20570
SSID ssj0005962
Score 2.080913
SecondaryResourceType review_article
Snippet Chronic lymphocytic leukemia (CLL) has a variable clinical course. Some patients have stable disease while others progress and require treatment. Levels of...
SourceID proquest
crossref
pubmed
informaworld
informahealthcare
SourceType Aggregation Database
Index Database
Publisher
StartPage 1046
SubjectTerms antibodies
Antigens, CD - genetics
Antigens, CD - metabolism
Antigens, Surface - genetics
Antigens, Surface - metabolism
Biomarkers, Tumor - genetics
Biomarkers, Tumor - metabolism
CD antigens
Chronic lymphocytic leukemia
Disease Progression
Gene Expression Profiling
Humans
immunophenotype
Leukemia, Lymphocytic, Chronic, B-Cell - classification
Leukemia, Lymphocytic, Chronic, B-Cell - diagnosis
Leukemia, Lymphocytic, Chronic, B-Cell - genetics
Leukemia, Lymphocytic, Chronic, B-Cell - pathology
microarray
Microarray Analysis
Models, Biological
Neoplasm Staging - methods
Prognosis
Title Surface profiles for subclassification of chronic lymphocytic leukemia
URI https://www.tandfonline.com/doi/abs/10.3109/10428194.2011.631370
https://www.ncbi.nlm.nih.gov/pubmed/22023531
https://search.proquest.com/docview/1015466839
Volume 53
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3db9MwELdKJyFe0Pju-FCQeKtSmthxnccNKBVigEQnjafIdhyBKM20Jkjjr-cudhKzlq-9RJVb51Lfz5c7--5nQp4xKiWLJA-VmcUhzEQaSlMUYSKmVKqI5dMcA8Xjd3xxwt6cJqeDQe1Xl1Rqon_srCu5ilahDfSKVbL_odnuptAAn0G_cAUNw_WfdPyxPi-kxlKn5uDthlphvKmVRpcYc4A6f1BbDtzx6gK0V-oLpGldmfqr-fZF-v7pW9fWIML-uDfci9otLmM6IXqnnyZdNG9s7cj7yfg1Pknfviq_2_prsCYb2esXeUDd4qtNNBt_mPhLEJjLwf0liOXWaSCeQcXyH_A67KKBcW1xs6tDfStsKYMd2nyTipvQ3usZ_EG-y_RTy5yK8lCcJWflNKL2XJJLpNr2i2tkD_kT2ZDsHR69PJr3uUEpt9vk7uFtzSWKeL5LwC8-zb5jvP3c5e9dYsH9fSzT-DTLfXLTBSPBoUXWLTIw69vk-rFLt7hD5g5gQQuwAO4fbAEsKIvAASzwABa0ALtLTuavli8WoTt4I9QsElWokfafmbiQUawSIQxPcpFoxQtlhNQxOLGcGWniRCcmjpVmEBYnSog0N3SqcnqPDNfl2jwgQSILCi8RnTYno3EmlE7FDJxczeQsSvMRCduhy84sv0oGcSkOddYOdYZDndmhHpHZ1vhmbkpu_tJT-FrIqga1hQUsdvtT16etxjKwvrilJtemrFEghCCcQ5QxIvetKru_EcfIJUWjg6sLfkhu9PPtERlW57V5DE5wpZ44yP4EJ86plg
link.rule.ids 314,780,784,27924,27925
linkProvider EBSCOhost
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Surface+profiles+for+subclassification+of+chronic+lymphocytic+leukemia&rft.jtitle=Leukemia+%26+lymphoma&rft.au=Huang%2C+Pauline+Y.&rft.au=Best%2C+O.+Giles&rft.au=Belov%2C+Larissa&rft.au=Mulligan%2C+Stephen+P.&rft.date=2012-06-01&rft.pub=Taylor+%26+Francis&rft.issn=1042-8194&rft.eissn=1029-2403&rft.volume=53&rft.issue=6&rft.spage=1046&rft.epage=1056&rft_id=info:doi/10.3109%2F10428194.2011.631370&rft.externalDocID=631370
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1042-8194&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1042-8194&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1042-8194&client=summon