Surface profiles for subclassification of chronic lymphocytic leukemia

• Published in: Leukemia & lymphoma Vol. 53; no. 6; pp. 1046 - 1056
• Main Authors: Huang, Pauline Y., Best, O. Giles, Belov, Larissa, Mulligan, Stephen P., Christopherson, Richard I.
• Format: Journal Article
• Language: English
• Published: United States Informa Healthcare 01.06.2012; Taylor & Francis
• Subjects: antibodies; Antigens, CD - genetics; Antigens, CD - metabolism; Antigens, Surface - genetics; Antigens, Surface - metabolism; Biomarkers, Tumor - genetics; Biomarkers, Tumor - metabolism; CD antigens; Chronic lymphocytic leukemia; Disease Progression; Gene Expression Profiling; Humans; immunophenotype; Leukemia, Lymphocytic, Chronic, B-Cell - classification; Leukemia, Lymphocytic, Chronic, B-Cell - diagnosis; Leukemia, Lymphocytic, Chronic, B-Cell - genetics; Leukemia, Lymphocytic, Chronic, B-Cell - pathology; microarray; Microarray Analysis; Models, Biological; Neoplasm Staging - methods; Prognosis
• ISSN: 1042-8194; 1029-2403
• DOI: 10.3109/10428194.2011.631370

Chronic lymphocytic leukemia (CLL) has a variable clinical course. Some patients have stable disease while others progress and require treatment. Levels of several cluster of differentiation (CD) antigens are known to correlate with prognosis and may be used to stratify patients according to risk. In this review, we summarize current information on surface CD antigens found on CLL, their pathological significance and their detection using CD antibody microarrays. The use of extensive immunophenotypic patterns or surface profiles as disease signatures for CLL subclassification, prognosis and patient management is discussed with a focus on triaging patients with CLL with progressive disease.