Interactome Analysis Identifies MSMEI_3879 as a Substrate of Mycolicibacterium smegmatis ClpC1

• Published in: Microbiology spectrum Vol. 11; no. 4; p. e0454822
• Main Authors: Ogbonna, Emmanuel C, Anderson, Henry R, Beardslee, Patrick C, Bheemreddy, Priyanka, Schmitz, Karl R
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 17.08.2023
• Subjects: Anti-Bacterial Agents - pharmacology; Bacterial Proteins - metabolism; Clp protease; Heat-Shock Proteins - genetics; Humans; interactome; Molecular Chaperones - metabolism; Mycobacterium; Mycobacterium smegmatis - metabolism; Mycobacterium tuberculosis; proteolysis; proteomics; Tuberculosis - microbiology; Clp protease; Mycobacterium; interactome; proteomics; proteolysis

The prevalence of drug-resistant Mycobacterium tuberculosis infections has prompted extensive efforts to exploit new drug targets in this globally important pathogen. ClpC1, the unfoldase component of the essential ClpC1P1P2 protease, has emerged as one particularly promising antibacterial target. H...