Effect of fucoidan on aspirin-induced stomach ulceration in rats

In this study, the effects of fucoidan on aspirin-induced ulcers in rats were evaluated: both biochemical and immunological parameters were taken into consideration. The status of stomach tissue glycogen storage and histological changes were also examined. Examination of basic biochemical parameters...

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Published inChemico-biological interactions Vol. 183; no. 1; pp. 249 - 254
Main Authors Choi, Jong-il, Raghavendran, Hanumatha Rao Balaji, Sung, Nak-Yun, Kim, Jae-Hun, Chun, Byeong Soo, Ahn, Dong Hyun, Choi, Hong-Seok, Kang, Keon-Wook, Lee, Ju-Woon
Format Journal Article
LanguageEnglish
Published Ireland Elsevier Ireland Ltd 05.01.2010
Subjects
Animals
Anti-Inflammatory Agents, Non-Steroidal - toxicity
Anti-Ulcer Agents - therapeutic use
Aspirin
Aspirin - toxicity
Blood Urea Nitrogen
Cytokines
Fucoidan
Gastric Mucosa - pathology
Glycogen
Glycogen - metabolism
Interferon-gamma - metabolism
Interleukin-10 - metabolism
Interleukin-6 - metabolism
Liver Function Tests
Male
Neutrophil Infiltration
Polysaccharides - therapeutic use
Rats
Rats, Wistar
Stomach Ulcer - chemically induced
Stomach Ulcer - drug therapy
Stomach Ulcer - pathology
Ulcer
Ulcer
Aspirin
Fucoidan
Cytokines
Glycogen
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Abstract In this study, the effects of fucoidan on aspirin-induced ulcers in rats were evaluated: both biochemical and immunological parameters were taken into consideration. The status of stomach tissue glycogen storage and histological changes were also examined. Examination of basic biochemical parameters showed significant ( p < 0.01) alterations in aspartate (AST) and alanine (ALT) transaminases in ulcer-induced rats. Also, moderate alterations ( p < 0.05) were observed in the levels of cholesterol and blood urea nitrogen (BUN). Histopathological examination showed neutrophil infiltration and inflammation in oxyntic cells with altered glycogen storage. Analysis of serum cytokines of aspirin-induced rats showed a moderate decrease in interleukin-10 (IL-10) with considerable increase of interleukin-6 (IL-6) and interferon-γ (INF-γ) when compared with control. Administration of fucoidan showed considerable ( p < 0.05) protection against ulceration by inhibiting the acute alterations of AST, ALT, cytokines and stomach glycogen. However, aggravated serum INF-γ was observed in the fucoidan-pretreated group. These findings suggest that the anti-ulcer property of fucoidan might contribute in protecting the inflammatory cytokine-mediated oxidative damage to gastric mucosa.
AbstractList In this study, the effects of fucoidan on aspirin-induced ulcers in rats were evaluated: both biochemical and immunological parameters were taken into consideration. The status of stomach tissue glycogen storage and histological changes were also examined. Examination of basic biochemical parameters showed significant (p&lt;0.01) alterations in aspartate (AST) and alanine (ALT) transaminases in ulcer-induced rats. Also, moderate alterations (p&lt;0.05) were observed in the levels of cholesterol and blood urea nitrogen (BUN). Histopathological examination showed neutrophil infiltration and inflammation in oxyntic cells with altered glycogen storage. Analysis of serum cytokines of aspirin-induced rats showed a moderate decrease in interleukin-10 (IL-10) with considerable increase of interleukin-6 (IL-6) and interferon-gamma (INF-gamma) when compared with control. Administration of fucoidan showed considerable (p&lt;0.05) protection against ulceration by inhibiting the acute alterations of AST, ALT, cytokines and stomach glycogen. However, aggravated serum INF-gamma was observed in the fucoidan-pretreated group. These findings suggest that the anti-ulcer property of fucoidan might contribute in protecting the inflammatory cytokine-mediated oxidative damage to gastric mucosa.
In this study, the effects of fucoidan on aspirin-induced ulcers in rats were evaluated: both biochemical and immunological parameters were taken into consideration. The status of stomach tissue glycogen storage and histological changes were also examined. Examination of basic biochemical parameters showed significant ( p < 0.01) alterations in aspartate (AST) and alanine (ALT) transaminases in ulcer-induced rats. Also, moderate alterations ( p < 0.05) were observed in the levels of cholesterol and blood urea nitrogen (BUN). Histopathological examination showed neutrophil infiltration and inflammation in oxyntic cells with altered glycogen storage. Analysis of serum cytokines of aspirin-induced rats showed a moderate decrease in interleukin-10 (IL-10) with considerable increase of interleukin-6 (IL-6) and interferon-γ (INF-γ) when compared with control. Administration of fucoidan showed considerable ( p < 0.05) protection against ulceration by inhibiting the acute alterations of AST, ALT, cytokines and stomach glycogen. However, aggravated serum INF-γ was observed in the fucoidan-pretreated group. These findings suggest that the anti-ulcer property of fucoidan might contribute in protecting the inflammatory cytokine-mediated oxidative damage to gastric mucosa.
In this study, the effects of fucoidan on aspirin-induced ulcers in rats were evaluated: both biochemical and immunological parameters were taken into consideration. The status of stomach tissue glycogen storage and histological changes were also examined. Examination of basic biochemical parameters showed significant (p<0.01) alterations in aspartate (AST) and alanine (ALT) transaminases in ulcer-induced rats. Also, moderate alterations (p<0.05) were observed in the levels of cholesterol and blood urea nitrogen (BUN). Histopathological examination showed neutrophil infiltration and inflammation in oxyntic cells with altered glycogen storage. Analysis of serum cytokines of aspirin-induced rats showed a moderate decrease in interleukin-10 (IL-10) with considerable increase of interleukin-6 (IL-6) and interferon-gamma (INF-gamma) when compared with control. Administration of fucoidan showed considerable (p<0.05) protection against ulceration by inhibiting the acute alterations of AST, ALT, cytokines and stomach glycogen. However, aggravated serum INF-gamma was observed in the fucoidan-pretreated group. These findings suggest that the anti-ulcer property of fucoidan might contribute in protecting the inflammatory cytokine-mediated oxidative damage to gastric mucosa.
Author Raghavendran, Hanumatha Rao Balaji
Kim, Jae-Hun
Kang, Keon-Wook
Choi, Jong-il
Chun, Byeong Soo
Sung, Nak-Yun
Lee, Ju-Woon
Ahn, Dong Hyun
Choi, Hong-Seok
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  organization: Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongeup 580-185, Republic of Korea
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  givenname: Nak-Yun
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  fullname: Sung, Nak-Yun
  organization: Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongeup 580-185, Republic of Korea
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  givenname: Jae-Hun
  surname: Kim
  fullname: Kim, Jae-Hun
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  givenname: Hong-Seok
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  fullname: Choi, Hong-Seok
  organization: College of Pharmacy, Chosun University, Gwangju 501-759, Republic of Korea
– sequence: 8
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  fullname: Kang, Keon-Wook
  organization: College of Pharmacy, Chosun University, Gwangju 501-759, Republic of Korea
– sequence: 9
  givenname: Ju-Woon
  surname: Lee
  fullname: Lee, Ju-Woon
  email: sjwlee@kaeri.re.kr
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/19788892$$D View this record in MEDLINE/PubMed
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Keywords Ulcer
Aspirin
Fucoidan
Cytokines
Glycogen
Language English
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Snippet In this study, the effects of fucoidan on aspirin-induced ulcers in rats were evaluated: both biochemical and immunological parameters were taken into...
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SubjectTerms Animals
Anti-Inflammatory Agents, Non-Steroidal - toxicity
Anti-Ulcer Agents - therapeutic use
Aspirin
Aspirin - toxicity
Blood Urea Nitrogen
Cytokines
Fucoidan
Gastric Mucosa - pathology
Glycogen
Glycogen - metabolism
Interferon-gamma - metabolism
Interleukin-10 - metabolism
Interleukin-6 - metabolism
Liver Function Tests
Male
Neutrophil Infiltration
Polysaccharides - therapeutic use
Rats
Rats, Wistar
Stomach Ulcer - chemically induced
Stomach Ulcer - drug therapy
Stomach Ulcer - pathology
Ulcer
Title Effect of fucoidan on aspirin-induced stomach ulceration in rats
URI https://dx.doi.org/10.1016/j.cbi.2009.09.015
https://www.ncbi.nlm.nih.gov/pubmed/19788892
https://search.proquest.com/docview/734192270
Volume 183
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