Examination of caspase-dependent apoptotic and necrotic changes in rat kidney exposed to different doses of permethrin

• Published in: Biotechnic & histochemistry Vol. 88; no. 2; pp. 76 - 85
• Main Authors: Guvenc, D, Kabak, YB, Atmaca, E, Aksoy, A, Guvenc, T
• Format: Journal Article
• Language: English
• Published: England Informa Healthcare 01.02.2013; Taylor & Francis
• Subjects: 3-phenoxybenzoic acid; Animals; Apoptosis; Benzoates - urine; caspase; Caspases - metabolism; Dose-Response Relationship, Drug; immunohistochemistry; Insecticides - toxicity; Kidney - drug effects; Kidney - enzymology; Male; Necrosis; permethrin; Permethrin - toxicity; Rats; Rats, Sprague-Dawley; Reference Standards; TUNEL; urine proteins

Abstract We investigated dose-related pathological alterations and apoptosis in rat kidney tissue exposed to permethrin. Histopathological findings, apoptotic cell death and urinary 3-phenoxybenzoic acid concentrations (3-PBA) were evaluated. Different doses of permethrin were administered to animal...