Anti-Influenza Prodrug Oseltamivir Is Activated by Carboxylesterase Human Carboxylesterase 1, and the Activation Is Inhibited by Antiplatelet Agent Clopidogrel - Shi, Deshi; Yang, Jian; Yang, Dongfang; LeCluyse, Edward L.; Black, Chris; You, Li; Akhlaghi, Fatemeh; Yan, Bingfang (The Journal of pharmacology and experimental therapeutics, 2006)
Keywords: Antiviral Agents - metabolism; Carboxylic Ester Hydrolases - antagonists & inhibitors; Carboxylic Ester Hydrolases - metabolism; Cell Line; Cell Survival - drug effects; Clopidogrel; Drug Interactions; Humans; Hydrolysis; Mass Spectrometry; Microsomes - drug effects; Microsomes - metabolism; Mutagenesis, Site-Directed; Oseltamivir - metabolism; Platelet Aggregation Inhibitors - pharmacology; Ticlopidine - analogs & derivatives; Ticlopidine - pharmacology; Transfection