No association between the TPH A218C polymorphism and personality traits in Japanese healthy subjects

• Published in: Progress in neuro-psychopharmacology & biological psychiatry Vol. 31; no. 2; pp. 395 - 398
• Main Authors: Suzuki, Akihito, Fukasawa, Takashi, Shiraishi, Hiroaki, Ishii, Genki, Oshino, Shingo, Aoshima, Toshiaki, Otani, Koichi
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Inc 30.03.2007; Elsevier
• Subjects: Adult; Analysis of Variance; Biological and medical sciences; Female; Healthy subjects; Humans; Japan; Male; Medical sciences; Neuropharmacology; Personality; Personality - genetics; Personality Assessment; Pharmacology. Drug treatments; Polymorphism, Genetic - genetics; Regression Analysis; TCI; TPH A218C polymorphism; Tryptophan Hydroxylase - genetics; Asia; Japan; ST; C; NS; Personality; TPH A218C polymorphism; TPH; P; SD; RD; 5-HIAA; CSF; HA; Healthy subjects; TCI; 5-HT; Human; Healthy subject; Japanese; Polymorphism

It has been suggested that the central serotonergic activity is implicated in personality traits. Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in serotonin synthesis. In the present study, the association between the TPH A218C polymorphism and personality traits assessed by the Temperame...