No association between the TPH A218C polymorphism and personality traits in Japanese healthy subjects

It has been suggested that the central serotonergic activity is implicated in personality traits. Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in serotonin synthesis. In the present study, the association between the TPH A218C polymorphism and personality traits assessed by the Temperame...

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Published inProgress in neuro-psychopharmacology & biological psychiatry Vol. 31; no. 2; pp. 395 - 398
Main Authors Suzuki, Akihito, Fukasawa, Takashi, Shiraishi, Hiroaki, Ishii, Genki, Oshino, Shingo, Aoshima, Toshiaki, Otani, Koichi
Format Journal Article
LanguageEnglish
Published Amsterdam Elsevier Inc 30.03.2007
Elsevier
Subjects
Adult
Analysis of Variance
Biological and medical sciences
Female
Healthy subjects
Humans
Japan
Male
Medical sciences
Neuropharmacology
Personality
Personality - genetics
Personality Assessment
Pharmacology. Drug treatments
Polymorphism, Genetic - genetics
Regression Analysis
TCI
TPH A218C polymorphism
Tryptophan Hydroxylase - genetics
Asia
Japan
ST
C
NS
Personality
TPH A218C polymorphism
TPH
P
SD
RD
5-HIAA
CSF
HA
Healthy subjects
TCI
5-HT
Human
Healthy subject
Japanese
Polymorphism
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Abstract It has been suggested that the central serotonergic activity is implicated in personality traits. Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in serotonin synthesis. In the present study, the association between the TPH A218C polymorphism and personality traits assessed by the Temperament and Character Inventory (TCI) was examined in 345 Japanese healthy subjects. The TPH A218C polymorphism was determined by a PCR-RFLP method. There were no significant differences in the seven dimension scores of TCI among the A/A, A/C, and C/C genotype groups by the one-way ANOVA. There was a significant negative correlation between age and the NS scores. Females showed significantly higher scores of HA, RD, and ST, and significantly lower scores of SD than males. The multiple regression analysis using age, gender, and the TPH genotype as independent variables also showed no significant association between any dimension score and the genotype. The present study thus suggests that the TPH A218C polymorphism does not affect personality traits in Japanese healthy subjects.
AbstractList It has been suggested that the central serotonergic activity is implicated in personality traits. Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in serotonin synthesis. In the present study, the association between the TPH A218C polymorphism and personality traits assessed by the Temperament and Character Inventory (TCI) was examined in 345 Japanese healthy subjects. The TPH A218C polymorphism was determined by a PCR-RFLP method. There were no significant differences in the seven dimension scores of TCI among the A/A, A/C, and C/C genotype groups by the one-way ANOVA. There was a significant negative correlation between age and the NS scores. Females showed significantly higher scores of HA, RD, and ST, and significantly lower scores of SD than males. The multiple regression analysis using age, gender, and the TPH genotype as independent variables also showed no significant association between any dimension score and the genotype. The present study thus suggests that the TPH A218C polymorphism does not affect personality traits in Japanese healthy subjects.
It has been suggested that the central serotonergic activity is implicated in personality traits. Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in serotonin synthesis. In the present study, the association between the TPH A218C polymorphism and personality traits assessed by the Temperament and Character Inventory (TCI) was examined in 345 Japanese healthy subjects. The TPH A218C polymorphism was determined by a PCR-RFLP method. There were no significant differences in the seven dimension scores of TCI among the A/A, A/C, and C/C genotype groups by the one-way ANOVA. There was a significant negative correlation between age and the NS scores. Females showed significantly higher scores of HA, RD, and ST, and significantly lower scores of SD than males. The multiple regression analysis using age, gender, and the TPH genotype as independent variables also showed no significant association between any dimension score and the genotype. The present study thus suggests that the TPH A218C polymorphism does not affect personality traits in Japanese healthy subjects.It has been suggested that the central serotonergic activity is implicated in personality traits. Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in serotonin synthesis. In the present study, the association between the TPH A218C polymorphism and personality traits assessed by the Temperament and Character Inventory (TCI) was examined in 345 Japanese healthy subjects. The TPH A218C polymorphism was determined by a PCR-RFLP method. There were no significant differences in the seven dimension scores of TCI among the A/A, A/C, and C/C genotype groups by the one-way ANOVA. There was a significant negative correlation between age and the NS scores. Females showed significantly higher scores of HA, RD, and ST, and significantly lower scores of SD than males. The multiple regression analysis using age, gender, and the TPH genotype as independent variables also showed no significant association between any dimension score and the genotype. The present study thus suggests that the TPH A218C polymorphism does not affect personality traits in Japanese healthy subjects.
Author Ishii, Genki
Otani, Koichi
Oshino, Shingo
Fukasawa, Takashi
Suzuki, Akihito
Shiraishi, Hiroaki
Aoshima, Toshiaki
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Keywords ST
C
NS
Personality
TPH A218C polymorphism
TPH
P
SD
RD
5-HIAA
CSF
HA
Healthy subjects
TCI
5-HT
Human
Healthy subject
Japanese
Polymorphism
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Snippet It has been suggested that the central serotonergic activity is implicated in personality traits. Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in...
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SubjectTerms Adult
Analysis of Variance
Biological and medical sciences
Female
Healthy subjects
Humans
Japan
Male
Medical sciences
Neuropharmacology
Personality
Personality - genetics
Personality Assessment
Pharmacology. Drug treatments
Polymorphism, Genetic - genetics
Regression Analysis
TCI
TPH A218C polymorphism
Tryptophan Hydroxylase - genetics
Title No association between the TPH A218C polymorphism and personality traits in Japanese healthy subjects
URI https://dx.doi.org/10.1016/j.pnpbp.2006.10.003
https://www.ncbi.nlm.nih.gov/pubmed/17116352
https://www.proquest.com/docview/20886927
https://www.proquest.com/docview/68996657
Volume 31
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