Specific requirements of nonbilayer phospholipids in mitochondrial respiratory chain function and formation

• Published in: Molecular biology of the cell Vol. 27; no. 14; pp. 2161 - 2171
• Main Authors: Baker, Charli D., Basu Ball, Writoban, Pryce, Erin N., Gohil, Vishal M.
• Format: Journal Article
• Language: English
• Published: United States The American Society for Cell Biology 15.07.2016
• Subjects: Cardiolipins - metabolism; Electron Transport - physiology; Endoplasmic Reticulum - metabolism; Mitochondria - metabolism; Mitochondrial Membranes - metabolism; Phosphatidylcholines - metabolism; Phosphatidylethanolamines - metabolism; Phospholipids - metabolism; Saccharomyces cerevisiae - metabolism

Mitochondrial membrane phospholipid composition affects mitochondrial function by influencing the assembly of the mitochondrial respiratory chain (MRC) complexes into supercomplexes. For example, the loss of cardiolipin (CL), a signature non–bilayer-forming phospholipid of mitochondria, results in d...