Evaluation of Fetal Exposures to Metals and Metalloids through Meconium Analyses: A Review

This paper surveys the existing scientific literature on metals concentrations in meconium. We examine some 32 papers that analyzed meconium for aluminum, arsenic, barium, calcium, chromium, copper, iron, lithium, magnesium, manganese, zinc, lead, mercury, manganese, molybdenum, nickel, phosphorus,...

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Published inInternational journal of environmental research and public health Vol. 18; no. 4; p. 1975
Main Authors Michelsen-Correa, Stephani, Martin, Clyde F., Kirk, Andrea B.
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 18.02.2021
MDPI
Subjects
Babies
Bibliographic literature
Birth defects
Cadmium
Cobalt
Copper
Diabetes
Feces
Heavy metals
Humans
Infant, Newborn
Lead content
Meconium
Metalloids - toxicity
Mines
Pesticides
Review
Scientific imaging
Zinc
biological monitoring
meconium
fetal exposure
heavy metals
fetus
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Abstract This paper surveys the existing scientific literature on metals concentrations in meconium. We examine some 32 papers that analyzed meconium for aluminum, arsenic, barium, calcium, chromium, copper, iron, lithium, magnesium, manganese, zinc, lead, mercury, manganese, molybdenum, nickel, phosphorus, lead, antimony, selenium, tin, vanadium, and zinc. Because of the lack of detail in the statistics it is not possible to do a rigorous meta-analysis. What stands out is that almost every study had subjects with seemingly large amounts of at least one of the metals. The significance of metals in meconium is not clear beyond an indication of exposure although some studies have correlated metals in meconium to a number of adverse outcomes. A number of outstanding questions have been identified that, if resolved, would greatly increase the utility of meconium analysis for assessment of long-term gestational metals exposures. Among these are questions of the developmental and long-term significance of metals detected in meconium, the kinetics and interactions among metals in maternal and fetal compartments and questions on best methods for meconium analyses.
AbstractList This paper surveys the existing scientific literature on metals concentrations in meconium. We examine some 32 papers that analyzed meconium for aluminum, arsenic, barium, calcium, chromium, copper, iron, lithium, magnesium, manganese, zinc, lead, mercury, manganese, molybdenum, nickel, phosphorus, lead, antimony, selenium, tin, vanadium, and zinc. Because of the lack of detail in the statistics it is not possible to do a rigorous meta-analysis. What stands out is that almost every study had subjects with seemingly large amounts of at least one of the metals. The significance of metals in meconium is not clear beyond an indication of exposure although some studies have correlated metals in meconium to a number of adverse outcomes. A number of outstanding questions have been identified that, if resolved, would greatly increase the utility of meconium analysis for assessment of long-term gestational metals exposures. Among these are questions of the developmental and long-term significance of metals detected in meconium, the kinetics and interactions among metals in maternal and fetal compartments and questions on best methods for meconium analyses.
This paper surveys the existing scientific literature on metals concentrations in meconium. We examine some 32 papers that analyzed meconium for aluminum, arsenic, barium, calcium, chromium, copper, iron, lithium, magnesium, manganese, zinc, lead, mercury, manganese, molybdenum, nickel, phosphorus, lead, antimony, selenium, tin, vanadium, and zinc. Because of the lack of detail in the statistics it is not possible to do a rigorous meta-analysis. What stands out is that almost every study had subjects with seemingly large amounts of at least one of the metals. The significance of metals in meconium is not clear beyond an indication of exposure although some studies have correlated metals in meconium to a number of adverse outcomes. A number of outstanding questions have been identified that, if resolved, would greatly increase the utility of meconium analysis for assessment of long-term gestational metals exposures. Among these are questions of the developmental and long-term significance of metals detected in meconium, the kinetics and interactions among metals in maternal and fetal compartments and questions on best methods for meconium analyses.This paper surveys the existing scientific literature on metals concentrations in meconium. We examine some 32 papers that analyzed meconium for aluminum, arsenic, barium, calcium, chromium, copper, iron, lithium, magnesium, manganese, zinc, lead, mercury, manganese, molybdenum, nickel, phosphorus, lead, antimony, selenium, tin, vanadium, and zinc. Because of the lack of detail in the statistics it is not possible to do a rigorous meta-analysis. What stands out is that almost every study had subjects with seemingly large amounts of at least one of the metals. The significance of metals in meconium is not clear beyond an indication of exposure although some studies have correlated metals in meconium to a number of adverse outcomes. A number of outstanding questions have been identified that, if resolved, would greatly increase the utility of meconium analysis for assessment of long-term gestational metals exposures. Among these are questions of the developmental and long-term significance of metals detected in meconium, the kinetics and interactions among metals in maternal and fetal compartments and questions on best methods for meconium analyses.
Author Kirk, Andrea B.
Martin, Clyde F.
Michelsen-Correa, Stephani
AuthorAffiliation 1 AAAS Science & Technology Policy Fellow Hosted by EPA Office of Chemical Safety and Pollution Prevention, Biopesticides and Pollution Prevention Division, Washington, DC 20004, USA; smcorrea@uw.edu
2 Department of Mathematics and Statistics, Texas Tech University, Lubbock, TX 79409, USA
3 Department of Occupational and Environmental Health, Milken Institute School of Public Health, George Washington University, Washington, DC 20052, USA; abkirk@gwu.edu
AuthorAffiliation_xml – name: 3 Department of Occupational and Environmental Health, Milken Institute School of Public Health, George Washington University, Washington, DC 20052, USA; abkirk@gwu.edu
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– name: 1 AAAS Science & Technology Policy Fellow Hosted by EPA Office of Chemical Safety and Pollution Prevention, Biopesticides and Pollution Prevention Division, Washington, DC 20004, USA; smcorrea@uw.edu
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  orcidid: 0000-0002-1182-3104
  surname: Kirk
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/33670707$$D View this record in MEDLINE/PubMed
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Keywords biological monitoring
meconium
fetal exposure
heavy metals
fetus
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Snippet This paper surveys the existing scientific literature on metals concentrations in meconium. We examine some 32 papers that analyzed meconium for aluminum,...
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Aggregation Database
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StartPage 1975
SubjectTerms Babies
Bibliographic literature
Birth defects
Cadmium
Cobalt
Copper
Diabetes
Feces
Heavy metals
Humans
Infant, Newborn
Lead content
Meconium
Metalloids - toxicity
Mines
Pesticides
Review
Scientific imaging
Zinc
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Title Evaluation of Fetal Exposures to Metals and Metalloids through Meconium Analyses: A Review
URI https://www.ncbi.nlm.nih.gov/pubmed/33670707
https://www.proquest.com/docview/2492319609
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Volume 18
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