Small-dose S(+)-ketamine reduces postoperative pain when applied with ropivacaine in epidural anesthesia for total knee arthroplasty

• Published in: Anesthesia and analgesia Vol. 92; no. 5; pp. 1290 - 1295
• Main Authors: HIMMELSEHER, Sabine, ZIEGLER-PITHAMITSIS, Doris, ARGIRIADOU, Helena, MARTIN, Jan, JELEN-ESSELBORN, Sabine, KOCHS, Eberhard
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott 01.05.2001
• Subjects: Aged; Amides - administration & dosage; Amides - adverse effects; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics - administration & dosage; Analgesics - adverse effects; Anesthesia; Anesthesia depending on type of surgery; Anesthesia, Epidural; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Anesthetics, Local - administration & dosage; Arthroplasty, Replacement, Knee; Biological and medical sciences; Double-Blind Method; Female; Humans; Ketamine - administration & dosage; Ketamine - adverse effects; Male; Medical sciences; Middle Aged; Orthopedic surgery. Maxillofacial surgery. Otorhinolaryngologic surgery. Stomatology. Ophtalmology. Investigation and treatment technics; Pain Measurement; Pain, Postoperative - prevention & control; Patient Satisfaction; Prospective Studies; Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors; Ropivacaine; Knee; Human; Postoperative; Enantiomer(+); Prosthesis; Low dose; Glutamate receptor; Ropivacaine; Knee disease; Local anesthetic; Prevention; Analgesia; Chemotherapy; Analgesic; Regional anesthesia; Orthopedic surgery; Pain; Ketamine; Extradural administration; Organic amide; Antagonist; NMDA receptor

Reduction of nociceptive input through blockade of N-methyl-D-aspartate (NMDA) receptors has been reported. We compared the effects of epidural S(+)-ketamine versus placebo on postoperative pain in a randomized, double-blinded study in 37 patients undergoing unilateral knee arthroplasty. After lumba...