Bottom-up approach to build osteon-like structure by cell-laden photocrosslinkable hydrogel

• Published in: Chemical communications (Cambridge, England) Vol. 48; no. 26; pp. 3170 - 3172
• Main Authors: Zuo, Yicong, Xiao, Wenqian, Chen, Xiaoqin, Tang, Yajun, Luo, Hongrong, Fan, Hongsong
• Format: Journal Article
• Language: English
• Published: England 01.01.2012
• Subjects: Biocompatibility; biomimetics; Cell Line, Tumor; Cell Survival; chemical communication; chemical compounds; chemical reactions; Cross-Linking Reagents - chemical synthesis; Cross-Linking Reagents - chemistry; Gelatin - chemical synthesis; Gelatin - chemistry; Human Umbilical Vein Endothelial Cells - cytology; Humans; hydrogels; Hydrogels - chemical synthesis; Hydrogels - chemistry; Methacrylates - chemical synthesis; Methacrylates - chemistry; Photochemical Processes; Polyethylene Glycols - chemical synthesis; Polyethylene Glycols - chemistry

Based on photocrosslinkable PEGDMA and GelMA hydrogels, two "bottom-up" approaches ("circle-and-cross" and "layer-by-layer") were successfully developed to construct osteon-like structures with microchannel networks. Significantly, the "layer-by-layer" approac...