Bottom-up approach to build osteon-like structure by cell-laden photocrosslinkable hydrogel

Based on photocrosslinkable PEGDMA and GelMA hydrogels, two "bottom-up" approaches ("circle-and-cross" and "layer-by-layer") were successfully developed to construct osteon-like structures with microchannel networks. Significantly, the "layer-by-layer" approac...

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Published inChemical communications (Cambridge, England) Vol. 48; no. 26; pp. 3170 - 3172
Main Authors Zuo, Yicong, Xiao, Wenqian, Chen, Xiaoqin, Tang, Yajun, Luo, Hongrong, Fan, Hongsong
Format Journal Article
LanguageEnglish
Published England 01.01.2012
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Abstract Based on photocrosslinkable PEGDMA and GelMA hydrogels, two "bottom-up" approaches ("circle-and-cross" and "layer-by-layer") were successfully developed to construct osteon-like structures with microchannel networks. Significantly, the "layer-by-layer" approach employing the GelMA hydrogel with a higher biocompatibility was more favorable for building biomimetic osteon.
AbstractList Based on photocrosslinkable PEGDMA and GelMA hydrogels, two "bottom-up" approaches ("circle-and-cross" and "layer-by-layer") were successfully developed to construct osteon-like structures with microchannel networks. Significantly, the "layer-by-layer" approach employing the GelMA hydrogel with a higher biocompatibility was more favorable for building biomimetic osteon.
Based on photocrosslinkable PEGDMA and GelMA hydrogels, two "bottom-up" approaches ("circle-and-cross" and "layer-by-layer") were successfully developed to construct osteon-like structures with microchannel networks. Significantly, the "layer-by-layer" approach employing the GelMA hydrogel with a higher biocompatibility was more favorable for building biomimetic osteon.Based on photocrosslinkable PEGDMA and GelMA hydrogels, two "bottom-up" approaches ("circle-and-cross" and "layer-by-layer") were successfully developed to construct osteon-like structures with microchannel networks. Significantly, the "layer-by-layer" approach employing the GelMA hydrogel with a higher biocompatibility was more favorable for building biomimetic osteon.
Author Xiao, Wenqian
Fan, Hongsong
Tang, Yajun
Zuo, Yicong
Luo, Hongrong
Chen, Xiaoqin
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Snippet Based on photocrosslinkable PEGDMA and GelMA hydrogels, two "bottom-up" approaches ("circle-and-cross" and "layer-by-layer") were successfully developed to...
Based on photocrosslinkable PEGDMA and GelMA hydrogels, two “bottom-up” approaches (“circle-and-cross” and “layer-by-layer”) were successfully developed to...
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SubjectTerms Biocompatibility
biomimetics
Cell Line, Tumor
Cell Survival
chemical communication
chemical compounds
chemical reactions
Cross-Linking Reagents - chemical synthesis
Cross-Linking Reagents - chemistry
Gelatin - chemical synthesis
Gelatin - chemistry
Human Umbilical Vein Endothelial Cells - cytology
Humans
hydrogels
Hydrogels - chemical synthesis
Hydrogels - chemistry
Methacrylates - chemical synthesis
Methacrylates - chemistry
Photochemical Processes
Polyethylene Glycols - chemical synthesis
Polyethylene Glycols - chemistry
Title Bottom-up approach to build osteon-like structure by cell-laden photocrosslinkable hydrogel
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