Bottom-up approach to build osteon-like structure by cell-laden photocrosslinkable hydrogel

Based on photocrosslinkable PEGDMA and GelMA hydrogels, two "bottom-up" approaches ("circle-and-cross" and "layer-by-layer") were successfully developed to construct osteon-like structures with microchannel networks. Significantly, the "layer-by-layer" approac...

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Published inChemical communications (Cambridge, England) Vol. 48; no. 26; pp. 3170 - 3172
Main Authors Zuo, Yicong, Xiao, Wenqian, Chen, Xiaoqin, Tang, Yajun, Luo, Hongrong, Fan, Hongsong
Format Journal Article
LanguageEnglish
Published England 01.01.2012
Subjects
Biocompatibility
biomimetics
Cell Line, Tumor
Cell Survival
chemical communication
chemical compounds
chemical reactions
Cross-Linking Reagents - chemical synthesis
Cross-Linking Reagents - chemistry
Gelatin - chemical synthesis
Gelatin - chemistry
Human Umbilical Vein Endothelial Cells - cytology
Humans
hydrogels
Hydrogels - chemical synthesis
Hydrogels - chemistry
Methacrylates - chemical synthesis
Methacrylates - chemistry
Photochemical Processes
Polyethylene Glycols - chemical synthesis
Polyethylene Glycols - chemistry
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Summary:Based on photocrosslinkable PEGDMA and GelMA hydrogels, two "bottom-up" approaches ("circle-and-cross" and "layer-by-layer") were successfully developed to construct osteon-like structures with microchannel networks. Significantly, the "layer-by-layer" approach employing the GelMA hydrogel with a higher biocompatibility was more favorable for building biomimetic osteon.
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ISSN:1359-7345
1364-548X
1364-548X
DOI:10.1039/c2cc16744a