Hypoglycemic effect and active ingredients screening of Isodon Japonicus based on network pharmacology and experimental validation

• Published in: Arabian journal of chemistry Vol. 16; no. 10; p. 105108
• Main Authors: Xian, Xiao, Chunyan, Li, Canyu, Wang, Huiqing, Zhu, Liaofan, Song, Xiaolong, Liu, Yusi, Lu, Pengfei, Yang, Nan, Zhang, Jintao, Xue
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.10.2023; Elsevier
• Subjects: Diabetes; Hypoglycemic ingredient; Isodon Japonicus; Mechanism; Network pharmacology; IJ; ITGB2; GO; FBG; HMGCR; ITGAL; Mechanism; SD; Hypoglycemic ingredient; Isodon Japonicus; Network pharmacology; PGR; Diabetes; HUVECs

[Display omitted] •The ingredient-target-pathway relationship was studied by network pharmacology.•11 hypoglycemic components, 12 targets and 130 pathways were found.•Cell test and animal experiments were used to confirm the hypoglycemic effects. Isodon Japonicus (IJ) has historically been widely us...