Brainstem serotonin neurons selectively gate retinal information flow to thalamus

• Published in: Neuron (Cambridge, Mass.) Vol. 111; no. 5; pp. 711 - 726.e11
• Main Authors: Reggiani, Jasmine D.S., Jiang, Qiufen, Barbini, Melanie, Lutas, Andrew, Liang, Liang, Fernando, Jesseba, Deng, Fei, Wan, Jinxia, Li, Yulong, Chen, Chinfei, Andermann, Mark L.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.03.2023
• Subjects: 5-HT1B; Animals; Axons - physiology; Calcium; dLGN; dorsal raphe nucleus; Geniculate Bodies - physiology; glutamate release; htr1b; Mice; neuromodulation; Receptor, Serotonin, 5-HT1B - metabolism; retinal ganglion cell axons; Retinal Ganglion Cells - physiology; serotonin; Serotonin - metabolism; thalamus; Thalamus - physiology; two-photon calcium imaging; retinal ganglion cell axons; neuromodulation; dorsal raphe nucleus; dLGN; serotonin; htr1b; 5-HT1B; two-photon calcium imaging; glutamate release; thalamus

Retinal ganglion cell (RGC) types relay parallel streams of visual feature information. We hypothesized that neuromodulators might efficiently control which visual information streams reach the cortex by selectively gating transmission from specific RGC axons in the thalamus. Using fiber photometry...