Epithelial–Mesenchymal Transition Induced by TNF-α Requires NF-κB–Mediated Transcriptional Upregulation of Twist1

• Published in: Cancer research (Chicago, Ill.) Vol. 72; no. 5; pp. 1290 - 1300
• Main Authors: Li, Chia-Wei, Xia, Weiya, Huo, Longfei, Lim, Seung-Oe, Wu, Yun, Hsu, Jennifer L., Chao, Chi-Hong, Yamaguchi, Hirohito, Yang, Neng-Kai, Ding, Qingqing, Wang, Yan, Lai, Yun-Ju, LaBaff, Adam M., Wu, Ting-Jung, Lin, Been-Ren, Yang, Muh-Hwa, Hortobagyi, Gabriel N., Hung, Mien-Chie
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Association for Cancer Research 01.03.2012
• Subjects: Animals; Antineoplastic agents; Biological and medical sciences; Breast Neoplasms - genetics; Breast Neoplasms - pathology; Carrier Proteins - metabolism; Cell Line, Tumor; Epithelial-Mesenchymal Transition; Female; Humans; I-kappa B Kinase - physiology; Inflammation - genetics; Intracellular Signaling Peptides and Proteins; Lung Neoplasms - secondary; Mammary Neoplasms, Experimental - pathology; Medical sciences; Mice; Mice, Inbred BALB C; Neoplasm Proteins - metabolism; NF-kappa B - metabolism; Nuclear Proteins - genetics; Pharmacology. Drug treatments; Transcriptional Activation; Transfection; Tumor Necrosis Factor-alpha - genetics; Tumor Necrosis Factor-alpha - pharmacology; Tumors; Twist-Related Protein 1 - genetics; Up-Regulation; Transcription factor NFκB; Epithelial mesenchymal transition; Transcription; Cell transformation; Tumor necrosis factor α; Cytokine

Proinflammatory cytokines produced in the tumor microenvironment facilitate tumor development and metastatic progression. In particular, TNF-α promotes cancer invasion and angiogenesis associated with epithelial–mesenchymal transition (EMT); however, the mechanisms underlying its induction of EMT in...