Exocytosis-related genes and response to methylphenidate treatment in adults with ADHD

• Published in: Molecular psychiatry Vol. 23; no. 6; pp. 1446 - 1452
• Main Authors: da Silva, B S, Cupertino, R B, Rovaris, D L, Schuch, J B, Kappel, D B, Müller, D, Bandeira, C E, Victor, M M, Karam, R G, Mota, N R, Rohde, L A, Contini, V, Grevet, E H, Bau, C H D
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.06.2018; Nature Publishing Group
• Subjects: 38/77; 631/208; 692/53/2423; Adult; Analysis; Attention Deficit and Disruptive Behavior Disorders - complications; Attention Deficit Disorder with Hyperactivity - drug therapy; Attention Deficit Disorder with Hyperactivity - genetics; Attention deficit hyperactivity disorder; Behavioral Sciences; Biological Psychology; Blood proteins; Care and treatment; Central Nervous System Stimulants; Childhood mental disorders; Dosage and administration; Exocytosis; Exocytosis - genetics; Exocytosis - physiology; Female; Genes; Genetic aspects; Genetic polymorphisms; Genetic research; Humans; Hyperactivity; Male; Medicine; Medicine & Public Health; Messenger RNA; Methylphenidate; Methylphenidate - pharmacology; Methylphenidate - therapeutic use; mRNA; Neurosciences; Oppositional defiant disorder; original-article; Outcome Assessment (Health Care); Pharmacodynamics; Pharmacogenetics; Pharmacogenomics; Pharmacotherapy; Polymorphism, Genetic; Practice guidelines (Medicine); Psychiatry; RNA; Short term; SNAP receptors; Stimulants; Synaptotagmin; Synaptotagmin I - genetics; Synaptotagmin I - metabolism; Syntaxin 1 - genetics; Syntaxin 1 - metabolism; Treatment Outcome; Vesicle-Associated Membrane Protein 2 - genetics; Vesicle-Associated Membrane Protein 2 - metabolism

Experimental studies have demonstrated that methylphenidate (MPH) modulates the synaptic vesicle trafficking and synaptotagmin-1 (SytI) mRNA levels. SytI is a regulatory protein of the SNARE complex, a neurotransmitter exocytosis mediator. Despite this evidence, most SNARE complex-related genes have...