Effect of resveratrol on cell cycle proteins in murine transplantable liver cancer
To study the antitumour activity of resveratrol and its effect on the expression of cell cycle proteins including cyclin D1, cyclin B1 and p34cdc2 in transplanted liver cancer of murine. Murine transplanted hepatoma H22 model was used to evaluate the in vivo antitumor activity of resveratrol. Follow...
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Published in | World journal of gastroenterology : WJG Vol. 9; no. 10; pp. 2341 - 2343 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
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United States
Department of Hepatobiliary Surgery, First Hospital of Xi'an Jiaotong University,Xi'an 710061, S haanxi Province, China
01.10.2003
Baishideng Publishing Group Inc |
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Abstract | To study the antitumour activity of resveratrol and its effect on the expression of cell cycle proteins including cyclin D1, cyclin B1 and p34cdc2 in transplanted liver cancer of murine.
Murine transplanted hepatoma H22 model was used to evaluate the in vivo antitumor activity of resveratrol. Following abdominal administration of resveratrol, the change in tumour size was recorded and the protein expression of cyclin D1, cyclin B1 and p34cdc2 in the tumor and adjacent noncancerous liver tissues were measured by immunohistochemistry.
Following treatment of H22 tumour bearing mice with resveratrol at 10 or 15 mg/kg bodyweight for 10 days, the growth of murine transplantable liver cancer was inhibited by 36.3% or 49.3%, respectively. The inhibitory effect was significant compared to that in control group (P<0.05). The level of expression of cyclin B1 and p34cdc2 protein was decreased in the transplantable murine hepatoma 22 treated with resveratrol whereas the expression of cyclin D1 protein did not change.
Resveratrol exhibits anti-tumour activities on murine hepatoma H22. The underlying anti-tumour mechanism of resveratrol might involve the inhibition of the cell cycle progression by decreasing the expression of cyclinB1 and p34cdc2 protein. |
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AbstractList | AIMTo study the antitumour activity of resveratrol and its effect on the expression of cell cycle proteins including cyclin D1, cyclin B1 and p34cdc2 in transplanted liver cancer of murine.METHODSMurine transplanted hepatoma H22 model was used to evaluate the in vivo antitumor activity of resveratrol. Following abdominal administration of resveratrol, the change in tumour size was recorded and the protein expression of cyclin D1, cyclin B1 and p34cdc2 in the tumor and adjacent noncancerous liver tissues were measured by immunohistochemistry.RESULTSFollowing treatment of H22 tumour bearing mice with resveratrol at 10 or 15 mg/kg bodyweight for 10 days, the growth of murine transplantable liver cancer was inhibited by 36.3% or 49.3%, respectively. The inhibitory effect was significant compared to that in control group (P<0.05). The level of expression of cyclin B1 and p34cdc2 protein was decreased in the transplantable murine hepatoma 22 treated with resveratrol whereas the expression of cyclin D1 protein did not change.CONCLUSIONResveratrol exhibits anti-tumour activities on murine hepatoma H22. The underlying anti-tumour mechanism of resveratrol might involve the inhibition of the cell cycle progression by decreasing the expression of cyclinB1 and p34cdc2 protein. AIM: To study the antitumour activity of resveratrol and its effect on the expression of ceil cycle proteins including cyclin D1, cyclin B1 and p34cdc2 in transplanted liver cancer of murine.METHODS: Murine transplanted hepatoma H22 model was used to evaluate the in vivo antitumor activity of resveratrol.Following abdominal administration of resveratrol, the change in tumour size was recorded and the protein expression of cyclin D1, cyclin B1 and p34cdc2 in the tumor and adjacent noncancerous liver tissues were measured by immunohistochemistry.RESULTS: Following treatment of H22 tumour bearing mice with resveratrol at 10 or 15 mg/kg bodyweight for 10 days,the growth of murine transplantable liver cancer was inhibited by 36.3% or 49.3%, respectively. The inhibitory effect was significant compared to that in control group (P<0.05).The level of expression of cyclin B1 and p34cdc2 protein was decreased in the transplantable murine hepatoma 22treated with resveratrol whereas the expression of cyclin D1 protein did not change.CONCLUSION: Resveratrol exhibits anti-tumour activities on murine hepatoma H22. The underlying anti-tumour mechanism of resveratrol might involve the inhibition of the cell cycle progression by decreasing the expression of cyclinB1 and p34cdc2 protein. To study the antitumour activity of resveratrol and its effect on the expression of cell cycle proteins including cyclin D1, cyclin B1 and p34cdc2 in transplanted liver cancer of murine. Murine transplanted hepatoma H22 model was used to evaluate the in vivo antitumor activity of resveratrol. Following abdominal administration of resveratrol, the change in tumour size was recorded and the protein expression of cyclin D1, cyclin B1 and p34cdc2 in the tumor and adjacent noncancerous liver tissues were measured by immunohistochemistry. Following treatment of H22 tumour bearing mice with resveratrol at 10 or 15 mg/kg bodyweight for 10 days, the growth of murine transplantable liver cancer was inhibited by 36.3% or 49.3%, respectively. The inhibitory effect was significant compared to that in control group (P<0.05). The level of expression of cyclin B1 and p34cdc2 protein was decreased in the transplantable murine hepatoma 22 treated with resveratrol whereas the expression of cyclin D1 protein did not change. Resveratrol exhibits anti-tumour activities on murine hepatoma H22. The underlying anti-tumour mechanism of resveratrol might involve the inhibition of the cell cycle progression by decreasing the expression of cyclinB1 and p34cdc2 protein. AIM: To study the antitumour activity of resveratrol and its effect on the expression of cell cycle proteins including cyclin D1, cyclin B1 and p34cdc2 in transplanted liver cancer of murine. METHODS: Murine transplanted hepatoma H22 model was used to evaluate the in vivo antitumor activity of resveratrol. Following abdominal administration of resveratrol, the change in tumour size was recorded and the protein expression of cyclin D1, cyclin B1 and p34cdc2 in the tumor and adjacent noncancerous liver tissues were measured by immunohistochemistry. RESULTS: Following treatment of H22 tumour bearing mice with resveratrol at 10 or 15 mg/kg bodyweight for 10 d, the growth of murine transplantable liver cancer was inhibited by 36.3% or 49.3%, respectively. The inhibitory effect was significant compared to that in control group ( P < 0.05). The level of expression of cyclin B1 and p34cdc2 protein was decreased in the transplantable murine hepatoma 22 treated with resveratrol whereas the expression of cyclin D1 protein did not change. CONCLUSION: Resveratrol exhibits anti-tumour activities on murine hepatoma H22. The underlying anti-tumour mechanism of resveratrol might involve the inhibition of the cell cycle progression by decreasing the expression of cyclinB1 and p34cdc2 protein. |
Author | Wu, Sheng-Li Yu, Liang Sun, Zhong-Jie Pan, Cheng-En |
AuthorAffiliation | Department of Hepatobiliary Surgery, First Hospital of Xi'an Jiaotong University,Xi'an 710061, S haanxi Province, China |
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Cites_doi | 10.1016/S0304-3835(00)00658-3 10.1002/ijc.10932 10.1016/S0024-3205(99)00410-5 10.1097/00006676-200211000-00024 10.1080/0031302021000035965-1 10.1097/00005344-200002000-00013 10.1093/jn/131.6.1844 10.1016/S0304-3835(01)00476-1 10.1093/carcin/23.9.1549 10.1358/dot.2002.38.8.820097 10.1016/S0041-008X(02)00014-5 10.1016/S0024-3205(02)02177-X 10.1046/j.1365-2141.2001.02746.x 10.1051/medsci/2003192173 10.3892/ijmm.11.3.317 10.1002/1097-0215(200102)9999:9999<::AID-IJC1156>3.0.CO;2-E |
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Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Correspondence to: Dr. Liang Yu, Department of Hepatobiliary Surgery, First Hospital of Xi’an Jiaotong University, Xi’an 710061, Shaanxi Province, China. yuliang@163.com Telephone: +86-29-5324009 Author contributions: All authors contributed equally to the work. |
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Snippet | To study the antitumour activity of resveratrol and its effect on the expression of cell cycle proteins including cyclin D1, cyclin B1 and p34cdc2 in... AIMTo study the antitumour activity of resveratrol and its effect on the expression of cell cycle proteins including cyclin D1, cyclin B1 and p34cdc2 in... AIM: To study the antitumour activity of resveratrol and its effect on the expression of ceil cycle proteins including cyclin D1, cyclin B1 and p34cdc2 in... AIM: To study the antitumour activity of resveratrol and its effect on the expression of cell cycle proteins including cyclin D1, cyclin B1 and p34cdc2 in... |
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SubjectTerms | Animals Antineoplastic Agents, Phytogenic - pharmacology Brief Reports CDC2 Protein Kinase - metabolism Cell Cycle Proteins - metabolism Cyclin B - metabolism Cyclin B1 Cyclin D1 - metabolism Liver Neoplasms - drug therapy Liver Neoplasms - metabolism Liver Neoplasms - pathology Mice Mice, Inbred BALB C Neoplasm Transplantation Resveratrol Stilbenes - pharmacology |
Title | Effect of resveratrol on cell cycle proteins in murine transplantable liver cancer |
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