Homeostatic IL-13 in healthy skin directs dendritic cell differentiation to promote TH2 and inhibit TH17 cell polarization

• Published in: Nature immunology Vol. 22; no. 12; pp. 1538 - 1550
• Main Authors: Mayer, Johannes U., Hilligan, Kerry L., Chandler, Jodie S., Eccles, David A., Old, Samuel I., Domingues, Rita G., Yang, Jianping, Webb, Greta R., Munoz-Erazo, Luis, Hyde, Evelyn J., Wakelin, Kirsty A., Tang, Shiau-Choot, Chappell, Sally C., von Daake, Sventja, Brombacher, Frank, Mackay, Charles R., Sher, Alan, Tussiwand, Roxane, Connor, Lisa M., Gallego-Ortega, David, Jankovic, Dragana, Le Gros, Graham, Hepworth, Matthew R., Lamiable, Olivier, Ronchese, Franca
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.12.2021; Nature Publishing Group
• Subjects: 631/250/2152/1566; 631/250/2504/133/2505; 631/250/2504/2506; Allergens; Biomedical and Life Sciences; Biomedicine; CD11b antigen; Cell differentiation; Dendritic cells; Dermis; GATA-3 protein; Helper cells; Immunology; Infectious Diseases; Interleukin 13; Interleukin 17; Interleukin 4; KLF4 protein; Lungs; Lymphocytes T; Lymphoid cells; Microbiota; Skin; Small intestine; Spleen; Stat6 protein; Thymic stromal lymphopoietin; Transcription factors

The signals driving the adaptation of type 2 dendritic cells (DC2s) to diverse peripheral environments remain mostly undefined. We show that differentiation of CD11b lo migratory DC2s—a DC2 population unique to the dermis—required IL-13 signaling dependent on the transcription factors STAT6 and KLF4...