Experimental Mild Traumatic Brain Injury Induces Functional Alteration of the Developing Hippocampus

• Published in: Journal of neurophysiology Vol. 103; no. 1; pp. 499 - 510
• Main Authors: Yu, Zhe, Morrison, Barclay, III
• Format: Journal Article
• Language: English
• Published: United States Am Phys Soc 01.01.2010; American Physiological Society
• Subjects: Aging - physiology; Animals; Brain Injuries - physiopathology; CA1 Region, Hippocampal - growth & development; CA1 Region, Hippocampal - injuries; CA1 Region, Hippocampal - physiopathology; CA3 Region, Hippocampal - growth & development; CA3 Region, Hippocampal - injuries; CA3 Region, Hippocampal - physiopathology; Dentate Gyrus - growth & development; Dentate Gyrus - injuries; Dentate Gyrus - physiopathology; Evoked Potentials; Hippocampus - growth & development; Hippocampus - injuries; Hippocampus - physiopathology; In Vitro Techniques; Microelectrodes; Neuronal Plasticity - physiology; Neurons - physiology; Rats; Time Factors

Columbia University, Department of Biomedical Engineering, New York City, New York Submitted 21 August 2009; accepted in final form 11 November 2009 ABSTRACT It is estimated that 1.5 million Americans suffer a traumatic brain injury (TBI) every year, of which 80% are considered mild injuries. Becaus...