A single-arm clinical trial of a 48-hour intravenous N-acetylcysteine protocol for treatment of acetaminophen poisoning

• Published in: Clinical toxicology (Philadelphia, Pa.) Vol. 52; no. 5; pp. 512 - 518
• Main Authors: Heard, K., Rumack, B. H., Green, J. L., Bucher-Bartelson, B., Heard, S., Bronstein, A. C., Dart, R. C.
• Format: Journal Article
• Language: English
• Published: England Informa Healthcare 01.06.2014; Taylor & Francis
• Subjects: Acetaminophen; Acetaminophen - blood; Acetaminophen - poisoning; Acetylcysteine; Acetylcysteine - administration & dosage; Acetylcysteine - adverse effects; Acetylcysteine - therapeutic use; Administration, Intravenous; Adolescent; Adult; Antidote; Antidotes - administration & dosage; Antidotes - adverse effects; Antidotes - therapeutic use; Chemical and Drug Induced Liver Injury - epidemiology; Chemical and Drug Induced Liver Injury - etiology; Chemical and Drug Induced Liver Injury - prevention & control; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Overdose; Female; Humans; Liver injury; Male; Poisoning; Prospective Studies; Time Factors; Transaminases - blood; Treatment Outcome; Young Adult; Acetylcysteine; Poisoning; Antidote; Acetaminophen; Liver injury

Abstract Introduction. Acetylcysteine prevents hepatic injury when administered soon after acetaminophen overdose. The most commonly used treatment protocols are a 72-hour oral and a 21-hour intravenous (IV) protocol. Between 1984 and 1994, 409 patients were enrolled in a study to describe the outco...