Clinical and Genetic Characteristics of Patients with Neurofibromatosis Type 1 and Pheochromocytoma

• Published in: The New England journal of medicine Vol. 354; no. 25; pp. 2729 - 2731
• Main Authors: Bausch, Birke, Borozdin, Wiktor, Neumann, Hartmut P.H
• Format: Journal Article
• Language: English
• Published: United States Massachusetts Medical Society 22.06.2006
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Genes, Neurofibromatosis 1; Germ-Line Mutation; Head and Neck Neoplasms - genetics; Heterozygote; Humans; Middle Aged; Neurofibromatosis 1 - complications; Neurofibromatosis 1 - genetics; Paraganglioma - genetics; Pheochromocytoma - genetics; Registries

To the Editor: Pheochromocytoma occurs in approximately 1 percent of patients with neurofibromatosis type 1. 1 Accordingly, germ-line mutations in the NF1 gene — the susceptibility gene for neurofibromatosis type 1 — are assumed to be one of the heritable causes of pheochromocytoma. 2 Given the prev...