Insulin-degrading Enzyme Regulates Extracellular Levels of Amyloid β-Protein by Degradation

• Published in: The Journal of biological chemistry Vol. 273; no. 49; pp. 32730 - 32738
• Main Authors: Qiu, Wei Qiao, Walsh, Dominic M., Ye, Zhen, Vekrellis, Konstantinos, Zhang, Jimin, Podlisny, Marcia B., Rosner, Marsha Rich, Safavi, Afshin, Hersh, Louis B., Selkoe, Dennis J.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 04.12.1998
• Subjects: Alzheimer Disease - metabolism; Amyloid beta-Peptides - metabolism; Animals; Cell Line; Culture Media, Conditioned; Humans; Hydrolysis; Insulysin - cerebrospinal fluid; Insulysin - isolation & purification; Insulysin - metabolism; Mice; Microglia - cytology; Microglia - enzymology

Excessive cerebral accumulation of the 42-residue amyloid β-protein (Aβ) is an early and invariant step in the pathogenesis of Alzheimer's disease. Many studies have examined the cellular production of Aβ from its membrane-bound precursor, including the role of the presenilin proteins therein,...