Effect of Familial Longevity on Frailty and Sarcopenia: A Case-Control Study

Familial longevity confers advantages in terms of health, functionality, and longevity. We sought to assess potential differences in frailty and sarcopenia in older adults according to a parental history of extraordinary longevity. A total of 176 community-dwelling subjects aged 65-80 years were rec...

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Published inInternational journal of environmental research and public health Vol. 20; no. 2; p. 1534
Main Authors Belenguer-Varea, Angel, Avellana-Zaragoza, Juan Antonio, Inglés, Marta, Cunha-Pérez, Cristina, Cuesta-Peredo, David, Borrás, Consuelo, Viña, José, Tarazona-Santabalbina, Francisco José
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 14.01.2023
MDPI
Subjects
Age
Aged
Aging
Caregivers
Case-Control Studies
Cholesterol
Cognitive ability
Comorbidity
Education
Frail Elderly
Frailty
Frailty - epidemiology
Gait
Gender
Geriatric Assessment - methods
Geriatrics
Humans
Informed consent
Insomnia
Interleukin 6
Life expectancy
Longevity
Muscles
Offspring
Older people
Pain
Phenotypes
Population
Questionnaires
Robust control
Sarcopenia
Sarcopenia - epidemiology
Sarcopenia - genetics
Sleep disorders
Spain
frailty
function
muscle
longevity
aging
heredity
interleukin-6
sarcopenia
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Abstract Familial longevity confers advantages in terms of health, functionality, and longevity. We sought to assess potential differences in frailty and sarcopenia in older adults according to a parental history of extraordinary longevity. A total of 176 community-dwelling subjects aged 65-80 years were recruited in this observational case-control study, pair-matched 1:1 for gender, age, and place of birth and residence: 88 centenarians' offspring (case group) and 88 non-centenarians' offspring (control group). The main variables were frailty and sarcopenia based on Fried's phenotype and the European Working Group on Sarcopenia in Older People (EWGSOP) definitions, respectively. Sociodemographics, comorbidities, clinical and functional variables, the presence of geriatric syndromes, and laboratory parameters were also collected. Related sample tests were applied, and conditional logistic regression was performed. Cases had a higher percentage of robust patients (31.8% vs. 15.9%), lower percentages of frailty (9.1% vs. 21.6%) and pre-frailty (59.1% vs. 62.5%) ( = 0.001), and lower levels of IL-6 ( = 0.044) than controls. The robust adjusted OR for cases was 3.00 (95% CI = 1.06-8.47, = 0.038). No significant differences in muscle mass were found. Familial longevity was also associated with less obesity, insomnia, pain, and polypharmacy and a higher education level and total and low-density lipoprotein cholesterol. The results suggest an inherited genetic component in the frailty phenotype, while the sarcopenia association with familial longevity remains challenging.
AbstractList Familial longevity confers advantages in terms of health, functionality, and longevity. We sought to assess potential differences in frailty and sarcopenia in older adults according to a parental history of extraordinary longevity. A total of 176 community-dwelling subjects aged 65-80 years were recruited in this observational case-control study, pair-matched 1:1 for gender, age, and place of birth and residence: 88 centenarians' offspring (case group) and 88 non-centenarians' offspring (control group). The main variables were frailty and sarcopenia based on Fried's phenotype and the European Working Group on Sarcopenia in Older People (EWGSOP) definitions, respectively. Sociodemographics, comorbidities, clinical and functional variables, the presence of geriatric syndromes, and laboratory parameters were also collected. Related sample tests were applied, and conditional logistic regression was performed. Cases had a higher percentage of robust patients (31.8% vs. 15.9%), lower percentages of frailty (9.1% vs. 21.6%) and pre-frailty (59.1% vs. 62.5%) ( = 0.001), and lower levels of IL-6 ( = 0.044) than controls. The robust adjusted OR for cases was 3.00 (95% CI = 1.06-8.47, = 0.038). No significant differences in muscle mass were found. Familial longevity was also associated with less obesity, insomnia, pain, and polypharmacy and a higher education level and total and low-density lipoprotein cholesterol. The results suggest an inherited genetic component in the frailty phenotype, while the sarcopenia association with familial longevity remains challenging.
Familial longevity confers advantages in terms of health, functionality, and longevity. We sought to assess potential differences in frailty and sarcopenia in older adults according to a parental history of extraordinary longevity. A total of 176 community-dwelling subjects aged 65–80 years were recruited in this observational case–control study, pair-matched 1:1 for gender, age, and place of birth and residence: 88 centenarians’ offspring (case group) and 88 non-centenarians’ offspring (control group). The main variables were frailty and sarcopenia based on Fried’s phenotype and the European Working Group on Sarcopenia in Older People (EWGSOP) definitions, respectively. Sociodemographics, comorbidities, clinical and functional variables, the presence of geriatric syndromes, and laboratory parameters were also collected. Related sample tests were applied, and conditional logistic regression was performed. Cases had a higher percentage of robust patients (31.8% vs. 15.9%), lower percentages of frailty (9.1% vs. 21.6%) and pre-frailty (59.1% vs. 62.5%) ( p = 0.001), and lower levels of IL-6 ( p = 0.044) than controls. The robust adjusted OR for cases was 3.00 (95% CI = 1.06–8.47, p = 0.038). No significant differences in muscle mass were found. Familial longevity was also associated with less obesity, insomnia, pain, and polypharmacy and a higher education level and total and low-density lipoprotein cholesterol. The results suggest an inherited genetic component in the frailty phenotype, while the sarcopenia association with familial longevity remains challenging.
Familial longevity confers advantages in terms of health, functionality, and longevity. We sought to assess potential differences in frailty and sarcopenia in older adults according to a parental history of extraordinary longevity. A total of 176 community-dwelling subjects aged 65–80 years were recruited in this observational case–control study, pair-matched 1:1 for gender, age, and place of birth and residence: 88 centenarians’ offspring (case group) and 88 non-centenarians’ offspring (control group). The main variables were frailty and sarcopenia based on Fried’s phenotype and the European Working Group on Sarcopenia in Older People (EWGSOP) definitions, respectively. Sociodemographics, comorbidities, clinical and functional variables, the presence of geriatric syndromes, and laboratory parameters were also collected. Related sample tests were applied, and conditional logistic regression was performed. Cases had a higher percentage of robust patients (31.8% vs. 15.9%), lower percentages of frailty (9.1% vs. 21.6%) and pre-frailty (59.1% vs. 62.5%) (p = 0.001), and lower levels of IL-6 (p = 0.044) than controls. The robust adjusted OR for cases was 3.00 (95% CI = 1.06–8.47, p = 0.038). No significant differences in muscle mass were found. Familial longevity was also associated with less obesity, insomnia, pain, and polypharmacy and a higher education level and total and low-density lipoprotein cholesterol. The results suggest an inherited genetic component in the frailty phenotype, while the sarcopenia association with familial longevity remains challenging.
Author Tarazona-Santabalbina, Francisco José
Cuesta-Peredo, David
Viña, José
Cunha-Pérez, Cristina
Belenguer-Varea, Angel
Avellana-Zaragoza, Juan Antonio
Inglés, Marta
Borrás, Consuelo
AuthorAffiliation 3 Freshage Research Group, Department of Physiotherapy, Faculty of Physiotherapy, University of Valencia, CIBERFES-ISCIII, INCLIVA, 46010 Valencia, Spain
4 Department of Quality Management, Hospital Universitario de la Ribera, 46600 Valencia, Spain
5 Freshage Research Group, Department of Physiology, Faculty of Medicine, University of Valencia, CIBERFES-ISCIII, INCLIVA, 46010 Valencia, Spain
2 School of Doctorate, Universidad Católica de Valencia San Vicente Martir, 46001 Valencia, Spain
1 Division of Geriatrics, Hospital Universitario de la Ribera, 46600 Valencia, Spain
6 Centro de Investigación Biomédica en Red Fragilidad y Envejecimiento Saludable (CIBERFES), 46010 Valencia, Spain
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Issue 2
Keywords frailty
function
muscle
longevity
aging
heredity
interleukin-6
sarcopenia
Language English
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Snippet Familial longevity confers advantages in terms of health, functionality, and longevity. We sought to assess potential differences in frailty and sarcopenia in...
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SubjectTerms Age
Aged
Aging
Caregivers
Case-Control Studies
Cholesterol
Cognitive ability
Comorbidity
Education
Frail Elderly
Frailty
Frailty - epidemiology
Gait
Gender
Geriatric Assessment - methods
Geriatrics
Humans
Informed consent
Insomnia
Interleukin 6
Life expectancy
Longevity
Muscles
Offspring
Older people
Pain
Phenotypes
Population
Questionnaires
Robust control
Sarcopenia
Sarcopenia - epidemiology
Sarcopenia - genetics
Sleep disorders
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Title Effect of Familial Longevity on Frailty and Sarcopenia: A Case-Control Study
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Volume 20
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