Sodium carboxymethylcellulose scaffolds and their physicochemical effects on partial thickness wound healing

• Published in: International journal of pharmaceutics Vol. 403; no. 1-2; pp. 73 - 82
• Main Authors: Ramli, Nor Amlizan, Wong, Tin Wui
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 17.01.2011; Elsevier
• Subjects: Animals; Bandages, Hydrocolloid - standards; Biological and medical sciences; Burns - pathology; Burns - therapy; carboxymethylcellulose; Carboxymethylcellulose Sodium - administration & dosage; Carboxymethylcellulose Sodium - chemistry; Chemical Phenomena; Disease Models, Animal; General pharmacology; Male; Materials Testing; Medical sciences; molecular weight; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; polymers; Rats; Rats, Sprague-Dawley; Skin - injuries; Skin - pathology; sodium; Sodium carboxymethylcellulose; Spectroscopy, Fourier Transform Infrared; Tensile Strength; tissue repair; Transepidermal water loss; Wound dressing; Wound Healing; Wound dressing; Wound healing; Transepidermal water loss; Sodium carboxymethylcellulose; Cellulose(carboxymethyl); Pharmaceutical technology; Wound; Polyelectrolyte; Dressing; Water loss; Healing agent; Cellulose derivatives; Medical device; Polyacid; Cellulose ether

Sodium carboxymethylcellulose (SCMC) scaffolds promote wound healing through modulating transepidermal water movement as a function of polymer molecular weight instead of carboxymethyl substitution degree or matrix pore size distribution. This study investigated critical physicochemical attributes o...