Intraarterial Transplantation of Mitochondria After Ischemic Stroke Reduces Cerebral Infarction

• Published in: Stroke: vascular and interventional neurology Vol. 3; no. 3
• Main Authors: Norat, Pedro, Sokolowski, Jennifer D., Gorick, Catherine M., Soldozy, Sauson, Kumar, Jeyan S., Chae, Youngrok, Yagmurlu, Kaan, Nilak, Joelle, Sharifi, Khadijeh A., Walker, Melanie, Levitt, Michael R., Klibanov, Alexander L., Yan, Zhen, Price, Richard J., Tvrdik, Petr, Kalani, Mohammad Yashar S.
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.05.2023; Wiley
• Subjects: cerebral; focused ultrasound; Ischemia; Mitochondria; stroke; transplantation; Ultrasonic imaging

Transplantation of autologous mitochondria into ischemic tissue may mitigate injury caused by ischemia and reperfusion. Using murine stroke models of middle cerebral artery occlusion, we sought to evaluate feasibility of delivery of viable mitochondria to ischemic brain parenchyma. We evaluated the...