Cluster analysis identifies characteristic phenotypes of asthma with accelerated lung function decline

• Published in: The Journal of asthma Vol. 51; no. 2; p. 113
• Main Authors: Sakagami, Takuro, Hasegawa, Takashi, Koya, Toshiyuki, Furukawa, Toshiki, Kawakami, Hidenori, Kimura, Yosuke, Hoshino, Yoshifumi, Sakamoto, Hirotaka, Shima, Kenjiro, Kagamu, Hiroshi, Suzuki, Ei-ichi, Narita, Ichiei
• Format: Journal Article
• Language: English
• Published: England 01.03.2014
• Subjects: Adolescent; Adrenal Cortex Hormones - therapeutic use; Adrenergic beta-2 Receptor Agonists - therapeutic use; Adult; Aged; Asthma - blood; Asthma - drug therapy; Asthma - genetics; Asthma - physiopathology; Child; Child, Preschool; Cluster Analysis; Female; Forced Expiratory Volume; Genotype; Humans; Immunoglobulin E - blood; Infant; Interleukin-13 - genetics; Leukotriene Antagonists - therapeutic use; Lung - physiopathology; Male; Middle Aged; Phenotype; Polymorphism, Single Nucleotide; Vital Capacity; Young Adult

While the majority of individuals with asthma retain normal lung function over time, some exhibit accelerated lung function decline. Preservation of lung function is an important aspect of asthma management. Whether the asthma guidelines can prevent lung function decline remains controversial. This...