Dynamics of the Humoral Immune Response to a Prime-Boost Ebola Vaccine: Quantification and Sources of Variation

• Published in: Journal of virology Vol. 93; no. 18; pp. e00579 - 19
• Main Authors: Pasin, Chloé, Balelli, Irene, Van Effelterre, Thierry, Bockstal, Viki, Solforosi, Laura, Prague, Mélanie, Douoguih, Macaya, Thiébaut, Rodolphe
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 15.09.2019
• Subjects: Immunology; Life Sciences; Vaccines and Antiviral Agents; Vaccinology; vaccine; antibody response; Ebola; mechanistic modeling

With no available licensed vaccines or therapies, the West African Ebola virus disease epidemic of 2014 to 2016 caused 11,310 deaths. Following this outbreak, the development of vaccines has been accelerated. Combining different vector-based vaccines as heterologous regimens could induce a durable i...