ADP-ribosylation factor–like 4C binding to filamin-A modulates filopodium formation and cell migration

• Published in: Molecular biology of the cell Vol. 28; no. 22; pp. 3013 - 3028
• Main Authors: Chiang, Tsai-Shin, Wu, Hsu-Feng, Lee, Fang-Jen S.
• Format: Journal Article
• Language: English
• Published: United States The American Society for Cell Biology 01.11.2017
• Subjects: Actin Cytoskeleton - metabolism; Actins; ADP-Ribosylation; ADP-Ribosylation Factors - metabolism; ADP-Ribosylation Factors - physiology; Animals; cdc42 GTP-Binding Protein - metabolism; Cell Movement - physiology; Filamins - metabolism; Filamins - physiology; HeLa Cells; Humans; Microfilament Proteins - metabolism; Neoplasm Metastasis - physiopathology; Neoplasms - metabolism; Pseudopodia - metabolism

Changes in cell morphology and the physical forces that occur during migration are generated by a dynamic filamentous actin cytoskeleton. The ADP-ribosylation factor–like 4C (Arl4C) small GTPase acts as a molecular switch to regulate morphological changes and cell migration, although the mechanism b...