In vitro and in vivo evaluation of antioxidant and antigenotoxic potential of Punica granatum leaf extract

• Published in: Pharmaceutical biology Vol. 50; no. 12; pp. 1523 - 1530
• Main Authors: Dassprakash, M. Velayutham, Arun, Renganathan, Abraham, Suresh K., Premkumar, Kumpati
• Format: Journal Article
• Language: English
• Published: England Informa Healthcare 01.12.2012; Taylor & Francis
• Subjects: Animals; Antimutagenic Agents - chemistry; Antimutagenic Agents - isolation & purification; Antimutagenic Agents - pharmacology; Antimutagenic Agents - toxicity; Antioxidants - chemistry; Antioxidants - isolation & purification; Antioxidants - pharmacology; Antioxidants - toxicity; Biomarkers - metabolism; Biphenyl Compounds - chemistry; Bone Marrow Cells - drug effects; Bone Marrow Cells - pathology; Catalase - metabolism; Chlorides - chemistry; DNA Damage - drug effects; Dose-Response Relationship, Drug; DPPH; Ferric Compounds - chemistry; FRAP; Free radical scavenging; Glutathione - metabolism; Glutathione Transferase - metabolism; Lipid Peroxidation - drug effects; Liver - drug effects; Liver - metabolism; Male; Mice; Micronuclei, Chromosome-Defective - drug effects; micronucleus; Micronucleus Tests; Oxidative Stress - drug effects; pBR322 DNA; phenolic content; Phenols - pharmacology; Picrates - chemistry; Plant Extracts - chemistry; Plant Extracts - isolation & purification; Plant Extracts - pharmacology; Plant Extracts - toxicity; Plant Leaves; Plants, Medicinal; Punicaceae - chemistry; Superoxide Dismutase - metabolism; total flavonoid

Context: Several studies have reported the antioxidant activity and potential therapeutic properties of Punica granatum L. (Lythraceae) fruit. Medicinal properties have also been attributed to other parts of P. granatum tree, which are rich in bioactive phytochemicals. Objective: To explore the phyt...