Analysis of Three-Dimensional Aerosol Deposition in Pharmacologically Relevant Terms: Beyond Black or White ROIs

• Published in: Journal of aerosol medicine Vol. 28; no. 2; pp. 116 - 129
• Main Authors: Greenblatt, Elliot Eliyahu, Winkler, Tilo, Harris, Robert Scott, Kelly, Vanessa Jane, Kone, Mamary, Venegas, Jose
• Format: Journal Article
• Language: English
• Published: United States Mary Ann Liebert, Inc 01.04.2015
• Subjects: Administration, Inhalation; Aerosols; Asthma - diagnostic imaging; Asthma - physiopathology; Bronchoconstriction; Female; Humans; Image Processing, Computer-Assisted; Lung - diagnostic imaging; Lung - physiopathology; Male; Multidetector Computed Tomography - instrumentation; Multimodal Imaging - instrumentation; Nebulizers and Vaporizers; Original Research; Positron-Emission Tomography - instrumentation; Sodium Chloride - administration & dosage; Sodium Chloride - chemistry; Young Adult; mucocilliary transport; ROIs; tissue dosing; PET-CT; partial volume effect; motion correction; spillover effect; heterogeneity; surface concentration
• ISSN: 1941-2711; 1941-2703; 1941-2703
• DOI: 10.1089/jamp.2013.1120

This article presents a novel methodological approach to evaluate images of aerosol deposition taken with PET-CT cameras. Traditionally, Black-or-White (BW) Regions of Interest (ROIs) are created to cover Anatomical Regions (ARs) segmented from the high-resolution CT. Such ROIs do not usually consid...