A Polymorphic p53 Response Element in KIT Ligand Influences Cancer Risk and Has Undergone Natural Selection

• Published in: Cell Vol. 155; no. 2; pp. 410 - 422
• Main Authors: Zeron-Medina, Jorge, Wang, Xuting, Repapi, Emmanouela, Campbell, Michelle R., Su, Dan, Castro-Giner, Francesc, Davies, Benjamin, Peterse, Elisabeth F.P., Sacilotto, Natalia, Walker, Graeme J., Terzian, Tamara, Tomlinson, Ian P., Box, Neil F., Meinshausen, Nicolai, De Val, Sarah, Bell, Douglas A., Bond, Gareth L.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 10.10.2013
• Subjects: Animals; Cell Proliferation; Genetic Predisposition to Disease; Genome-Wide Association Study; Humans; Male; Mice; Polymorphism, Single Nucleotide; Response Elements; Selection, Genetic; Stem Cell Factor - genetics; Testicular Neoplasms - genetics; Transcription, Genetic; Tumor Suppressor Protein p53 - metabolism

The ability of p53 to regulate transcription is crucial for tumor suppression and implies that inherited polymorphisms in functional p53-binding sites could influence cancer. Here, we identify a polymorphic p53 responsive element and demonstrate its influence on cancer risk using genome-wide data se...