Plasmodium gallinaceum: A Refractory Mechanism of Ookinete Killing in the Mosquito, Anopheles gambiae

• Published in: Experimental parasitology Vol. 80; no. 4; pp. 583 - 595
• Main Authors: Vernick, K.D., Fujioka, H., Seeley, D.C., Tandler, B., Aikawa, M., Miller, L.H.
• Format: Journal Article
• Language: English
• Published: San Diego, CA Elsevier Inc 01.06.1995; Elsevier
• Subjects: ANIMAL DEVELOPMENTAL STAGES; Animals; Anopheles - genetics; Anopheles - parasitology; ANOPHELES GAMBIAE; Biological and medical sciences; Chickens; Culicidae; DEATH; DISEASE RESISTANCE; DISEASE VECTORS; Esterases - genetics; ETAPAS DEL DESARROLLO ANIMAL; Female; Fundamental and applied biological sciences. Psychology; GENE; GENES; Genes, Insect; GENETIC INHERITANCE; GENETIC REGULATION; GENETICA; GENETICS; GENETIQUE; GENOTIPOS; GENOTYPE; GENOTYPES; HEREDITE; HERENCIA GENETICA; INFECCIONES POR PROTOZOOS; INFECTIONS; Insect Vectors - genetics; Insect Vectors - parasitology; INTESTIN; INTESTINES; INTESTINOS; MALARIA; Medically important nuisances and vectors, pests of stored products and materials: population survey and control; Microscopy, Electron; MIDGUT; MORT; MUERTE; OOCYSTS; PATHOGENESE; PATHOGENESIS; PATOGENESIS; Phenotype; PLASMODIUM; PLASMODIUM GALLINACEUM; Plasmodium gallinaceum - physiology; Plasmodium gallinaceum - ultrastructure; PROTOZOAL INFECTIONS; PROTOZOOSE; RESISTANCE AUX MALADIES; RESISTENCIA A LA ENFERMEDAD; STADE DE DEVELOPPEMENT ANIMAL; SUSCEPTIBILITY; ULTRAESTRUCTURA; ULTRASTRUCTURE; VECTEUR DE MALADIE; VECTORES; VECTORS; Vectors. Intermediate hosts; Protozoa; Protozoal disease; Genetic inheritance; Ookinete; Malaria; Midgut; Insecta; Parasite; Host agent relation; Parasitosis; Plasmodium gallinaceum; Refractoriness; Immunity; Infection; Developmental arrest; Sensitivity resistance; Anopheles gambiae; Arthropoda; Pathogenic; Culicidae; Invertebrata; Sporozoa; Vector; Diptera

We have identified a mechanism for refractoriness to a bird malaria, Plasmodium gallinaceum, in the African vector of human malaria, Anopheles gambiae. Oocysts fail to develop in the refractory mosquitoes as a result of ookinete death which occurs within 27 hr of midgut invasion. Ultrastructural stu...