Targeted and multifunctional arene ruthenium chemotherapeutics
The introduction of multifunctionalities for tumour targeting is becoming a popular strategy toward the development of new therapeutic agents. In particular, the multifaceted potential of ruthenium(II)-arene complexes show great promise as chemotherapeutics. An ever-increasing number of papers deali...
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| Published in | Dalton transactions : an international journal of inorganic chemistry Vol. 40; no. 41; pp. 10793 - 10800 |
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| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
England
01.01.2011
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| Subjects | |
| Online Access | Get full text |
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| Abstract | The introduction of multifunctionalities for tumour targeting is becoming a popular strategy toward the development of new therapeutic agents. In particular, the multifaceted potential of ruthenium(II)-arene complexes show great promise as chemotherapeutics. An ever-increasing number of papers dealing with the integration of ruthenium complexes with biologically active molecules to derive bioorganometallic molecules of chemotherapeutic significance have been published in recent years. This perspective review presents a short overview of multifunctional ruthenium-based drugs, especially those containing arene ruthenium complexes, with the emphasis on the combination of photosensitizers with ruthenium complexes for the preparation of novel multifunctional photodynamic therapy agents. |
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| AbstractList | The introduction of multifunctionalities for tumour targeting is becoming a popular strategy toward the development of new therapeutic agents. In particular, the multifaceted potential of ruthenium(II)-arene complexes show great promise as chemotherapeutics. An ever-increasing number of papers dealing with the integration of ruthenium complexes with biologically active molecules to derive bioorganometallic molecules of chemotherapeutic significance have been published in recent years. This perspective review presents a short overview of multifunctional ruthenium-based drugs, especially those containing arene ruthenium complexes, with the emphasis on the combination of photosensitizers with ruthenium complexes for the preparation of novel multifunctional photodynamic therapy agents. |
| Author | Smith, Gregory S Therrien, Bruno |
| Author_xml | – sequence: 1 givenname: Gregory S surname: Smith fullname: Smith, Gregory S organization: University of Cape Town, Department of Chemistry, Rondebosch, 7701, Cape Town, South Africa – sequence: 2 givenname: Bruno surname: Therrien fullname: Therrien, Bruno |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/21858344$$D View this record in MEDLINE/PubMed |
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