Cinacalcet Reduces the Set Point of the PTH-Calcium Curve

• Published in: Journal of the American Society of Nephrology Vol. 19; no. 12; pp. 2430 - 2436
• Main Authors: VALLE, Casimiro, RODRIGUEZ, Mariano, SANTAMARIA, Rafael, ALMADEN, Yolanda, RODRIGUEZ, Maria E, CANADILLAS, Sagrario, MARTIN-MALO, Alejandro, ALJAMA, Pedro
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society of Nephrology 01.12.2008
• Subjects: Adult; Albumins - metabolism; Alkaline Phosphatase - metabolism; Biological and medical sciences; Calcium - blood; Calcium - metabolism; Cinacalcet Hydrochloride; Clinical Research; Female; Humans; Hyperparathyroidism - metabolism; Hyperparathyroidism, Secondary - metabolism; Male; Medical sciences; Middle Aged; Naphthalenes - pharmacology; Nephrology. Urinary tract diseases; Parathyroid Glands - metabolism; Parathyroid Hormone - metabolism; Renal Dialysis; Nephrology; Calcimimetic agent; Calcium; Parathyroid hormone; Peptide hormone; Curve; Antihormone; Cinacalcet; Inorganic element; Urology

The calcimimetic cinacalcet increases the sensitivity of the parathyroid calcium-sensing receptor to calcium and therefore should produce a decrease in the set point of the parathyroid hormone (PTH)-calcium curve. For investigation of this hypothesis, nine long-term hemodialysis patients with second...