Cystatin B Promotes the Proliferation, Migration, and Invasion of Intrahepatic Cholangiocarcinoma

• Published in: Current oncology (Toronto) Vol. 32; no. 2; p. 56
• Main Authors: Zhang, Dai, Sun, Bao-Ye, Wu, Jing-Fang, Wang, Zhu-Tao, Zheng, Su-Su, Sun, Guo-Qiang, Gao, Xu-Kang, Zhou, Jian, Fan, Jia, Hu, Bo, Qiu, Shuang-Jian, Zhang, Bo-Heng
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI 21.01.2025; MDPI AG
• Subjects: Animals; Bile Duct Neoplasms - genetics; Bile Duct Neoplasms - metabolism; Bile Duct Neoplasms - pathology; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cholangiocarcinoma - genetics; Cholangiocarcinoma - metabolism; Cholangiocarcinoma - pathology; CSTB; Cystatin B - genetics; Cystatin B - metabolism; Female; Humans; intrahepatic cholangiocarcinoma; invasion; Male; Mice; Mice, Nude; Middle Aged; migration; Neoplasm Invasiveness; Prognosis; proliferation; migration; CSTB; invasion; proliferation; intrahepatic cholangiocarcinoma

Background and Aims: Cystatin B (CSTB) has been demonstrated to play a significant role in the pathogenesis of a number of diseases, including the evolution and progression of multiple cancers. Nevertheless, the function of CSTB in intrahepatic cholangiocarcinoma (iCCA) is yet to be fully elucidated...