Tryptophan hydroxylase 2 gene is associated with major depression and antidepressant treatment response

• Published in: Progress in neuro-psychopharmacology & biological psychiatry Vol. 33; no. 4; pp. 637 - 641
• Main Authors: Tsai, Shih-Jen, Hong, Chen-Jee, Liou, Ying-Jay, Yu, Younger W-Y, Chen, Tai-Jui, Hou, Sheue-Jane, Yen, Feng-Chang
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Inc 15.06.2009; Elsevier
• Subjects: Adult; Adult and adolescent clinical studies; Antidepressant; Antidepressive Agents - therapeutic use; Biological and medical sciences; Citalopram; Depression; Depressive Disorder, Major - drug therapy; Depressive Disorder, Major - genetics; Female; Fluoxetine; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Major depressive disorders; Male; Medical sciences; Middle Aged; Mood disorders; Neuropharmacology; Pharmacogenetics; Pharmacology. Drug treatments; Polymorphism; Polymorphism, Single Nucleotide - genetics; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease); Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychopharmacology; Serotonin Uptake Inhibitors - therapeutic use; Taiwan; Tryptophan Hydroxylase - genetics; Tryptophan hydroxylase 2; Asia; China; Taiwan; Antidepressant; Pharmacogenetics; MDD; TPH; SSRI; SNP; Tryptophan hydroxylase 2; LD; HPA; SCAN; CHB; HAM-D; Major depressive disorders; Polymorphism; Mood disorder; Genetic variability; Serotonin; Healthy subject; Fluoxetine; Psychotropic; Etiopathogenesis; Depression; Reuptake inhibitor; Selective serotonin reuptake inhibitor; Citalopram; Treatment; Gene; Genetics; Antidepressant agent; Comparative study

Tryptophan hydroxylase-2 (TPH2) is the rate-limiting biosynthetic isoenzyme for serotonin that is preferentially expressed in the brain and has been implicated in the pathogenesis of major depressive disorder (MDD) and in the mechanism of antidepressant action. This study aimed to investigate whethe...